【摘要】 目的:探讨自然流产次数与自然流产夫妇染色体异常的关系。方法:收集因自然流产进行染色体检查的1 784对夫妇的基本信息,其中1次流产者663对,2次流产者869对,≥3次者252对,行外周血染色体分析。结果:1次流产组检出染色体异常夫妇27对,异常率为4.07%(27/663);2次流产组检出31对,异常率3.57%(31/869);≥3次组检出18对,异常率7.14%(18/252),比较不同流产次数组染色体异常构成比,无显著性差异(χ2分别为0.252、3.639、5.922,P均>0.05)。1 784对(3 568例)自然流产夫妇中共发现染色体异常核型77例,占2.16%(77/3 568),其中结构异常49例,占异常核型的63.64%(49/77),数目异常28例,占异常核型的36.36%(28/77),且结构异常多于数目异常,差异有统计学意义(χ2=5.79,P<0.05)。结论:自然流产次数与夫妇双方染色体异常之间无相关性,建议在1次自然流产后即行夫妇双方染色体检测。更多还原

【Abstract】 Objective: To investigate the relationship between the frequency of spontaneous abortion and the chromosome abnormality in couples with spontaneous abortion. Methods:The information of 1 784 couples with the history of spontaneous abortion were collected and the chromosome from peripheral blood of this couples was detected. Six hundred and sixty-three couples experienced spontaneous abortion once. Eight hundred and sixty-nice couples experienced spontaneous abortion twice. Two hundred and fifty-two couples experienced spontaneous abortion 3 times or more. Results:In the group of the couples who had experienced spontaneous abortion once, 27 couples showed abnormal karyotypes, accounting for 4.07%(27/663). In the group of the couples who had experienced spontaneous abortion twice,31 couples were observed with abnormal karyotypes, accounting for 3.57%(31/869). In the group of the couples who had experienced spontaneous abortion three times or more, 18 couples had chromosome abnormality, accounting for 7.14%(18/252). Statistical analysis was carried out on the chromosome abnormality rates among the three groups. Difference was not significant(χ2=0.252,3.639,5.922, P> 0.05).In 1 784 couples, 77 cases of abnormal karyotype were found, accounting for 2.16%(77/3 568) of all patient, with 49 cases of structural abnormalities and 28 cases of numerical abnormalities, accounting for 63.64%(49/77) and 36.36%(28/77), respectively. Conclusion:There is no correlation between the frequency of spontaneous abortion and the chromosome abnormality. If possible, the couples who have experienced spontaneous abortion once should have chromosome test.更多还原