【摘要】 Girdin蛋白是一种肌动蛋白结合蛋白,该蛋白具有复杂的分子结构并且参与多种与癌症发生相关的信号通路。这些生物学特性导致其与恶性肿瘤的增殖与侵袭紧密相关。近年来研究显示Girdin蛋白与乳腺癌的发生发展也有着密切的关系。Girdin蛋白在乳腺癌细胞中的表达,不仅能够促进乳腺癌的进展,还能够影响转移及预后。因此Girdin蛋白有望作为一个独立的生物学标志物,为乳腺癌治疗提供新的方向。更多还原

【Abstract】 Girdin protein is a kind of actin binding protein,which has the complex molecular structure and takes part in a variety of signaling pathways related with causing cancer.The biological characteristics of Girdin protein have close association with the proliferation and invasion of malignant tumor.Recent studies have shown that Girdin protein is closely related with occurrence and progress of breast cancer.Girdin protein expression in breast cancer cells can not only promote the progress of breast cancer,but also affect the lymph node metastasis and prognosis.Therefore Girdin protein is expected as an independent biomarker to provide a new direction for breast cancer treatment.更多还原