【摘要】 目的:探索¹⁸F-FDG和^99mTc-MIBI双核素心肌代谢/灌注显像（DISA）及门控心肌灌注显像在糖尿病心肌损害早期诊断中的临床价值。方法:32例糖尿病患者及26例正常志愿者行双核素心肌代谢/灌注显像及门控心肌灌注显像,评价糖尿病患者及正常志愿者心肌缺血、存活及心功能状况。结果:32例糖尿病患者中有21例（21/32,65.6%）,共47个区域出现心肌血流灌注显像异常,表现为非节段性、散在的多发放射性核素分布稀疏区,但在心肌代谢显像上均有¹⁸F-FDG核素摄取,即血流灌注/代谢不匹配,提示有心肌损害并存活。26例正常志愿者中双核素心肌代谢灌注显像未见明显异常。与正常志对照组比较,糖尿病患者出现心肌血流灌注异常的概率明显增高（P<0.01）,但是两组的心肌代谢未见明显差异。糖尿病组及正常对照组左室射血分数（LVEF）分别为（54.3±7.2）%及（67.3±4.9）%,二者比较差异有统计学意义（P<0.05）。结论:本研究结果表明¹⁸F-FDG和^99mTc-MIBI双核素心肌代谢/灌注显像一次显像可同时得到灌注和代谢两种信息,并可同时采用门控心肌灌注显像评价心脏功能,有助于糖尿病心脏损害的早期诊断并指导治疗。更多还原

【Abstract】 Objective To explore the diagnostic value of ¹⁸F-FDG/^99mTc-MIBI dual-isotope SPECT and gated myocardial imaging in early diagnosis of diabetes-induced myocardial damage.Methods 32 patients with diabetes and 26 healthy volunteers received ¹⁸F-FDG/^99mTc-MIBI dual-isotope SPECT and gated myocardial imaging for assessing myocardial ischemia,viability status,and cardiac function.Results Myocardial perfusion abnormalitieswere observed in 47 regions on myocardial perfusion imagingin 21 of 32（65.6%）patients with diabetes,showing perfusion/metabolism mismatched and suggesting viable myocardium.All the volunteers were normal on DISA.As compared with the normal control group,the positive rate of DISA in diabetic patients was significantly higher（P<0.01）.Left ventricular ejection fraction（LVEF） was（54.3±7.2%） and（67.3±4.9%）respectively,the difference was statistically significant（P<0.05）.Conclusions ¹⁸F-FDG/^99mTc-MIBI dualisotope SPECT and gated myocardial imaging can assess myocardial ischemia,viability and cardiac function in diabetic patients,and it is helpful for the early diagnosis of cardiac damage in patients with diabetes mellitus.更多还原