【摘要】 目的:比较HIVDB（7.0.1）、ANRS（25₀9/2015）、REGA（9.1.0）和HIV GRADE（12/2015）4种解释系统对HIV-1基因型耐药结果解释的一致性。方法:选取我国3种主要HIV-1流行亚型和流行重组模式（B’、CRF01_AE和CRF07_BC）,每种选取200条序列,共600条序列。分别用4种解释系统进行耐药结果分析,分为耐药（R）、中度耐药（I）和敏感（S）3个水平。对4种结果进行统计学分析。结果:4种系统基因型耐药解释结果比较相关性较高（r均>0.57,P均<0.01）。针对亚型来说,CRF07_BC的解释结果相关性最高,其次为B’亚型,CRF01_AE略低。结论:对于我国主要流行的HIV来说,4种解释系统对11种常用的抗病毒治疗药物耐药结果的解释具有较好的一致性。更多还原

【Abstract】 Objective:To compare the correlation of four drug-resistance interpretation system including HIVDB, ANRS,REGA and HIV GRADE for testing HIV-1 genotype drug resistance.Methods:Trendy subtypes and restructuring model of HIV-1including B’,CRF01_AE and CRF07_BC were selected,each genotype was 200 series,600 samples were analyzed by four drug-resistance interpretation system, the results were divided into three levels including resistance(R), possible drug- resistance(I) and susceptible(S).Results:Four drug-resistance interpretation system had a high correlation in genotypic drug-resistanceconsequence(rs>0.57, P<0.01),CRF07_BC had the highest correlation,followed by subtype B,CRF01_AE was slightlylower.Conclusion:Four drug-resistance interpretation system has a high correlation in analyzing antiviral drug resistance for majorepidemic of HIV in China.更多还原