【摘要】 目的探讨免疫球蛋白在早产儿败血症辅助治疗中的作用机理及对治疗效果进行评估。方法 2012年1月—2014年12月在我院新生儿科诊治的早产儿败血症共118例,按诊断日期的单双号随机分成观察组58例和对照组60例,2组均给予常规抗感染治疗,观察组自诊断败血症之日起辅以免疫球蛋白治疗,每次400 mg/kg,每日1次,连用3 d,比较2组临床及实验室指标的恢复时间、病死率差异有无统计学意义,并比较2组治疗前后血清Ig G水平有无差异。结果观察组临床恢复时间早于对照组[(6.93±1.43)d vs.(8.47±2.13)d,P<0.05];观察组血WBC、PLT、CRP、PCT恢复正常的时间均较对照组早(P<0.05);观察组的病死率低于对照组(5.2%vs.16.7%,P<0.05);观察组治疗后血清Ig G水平较治疗前显著升高[(6.29±1.09)g/L vs.(11.14±1.79)g/L,P<0.01)],而对照组治疗前后血清Ig G水平差异无统计学意义[(6.37±1.14)g/L vs.(6.33±0.97)g/L,P>0.05]。结论免疫球蛋白可提高早产儿血清Ig G水平,增强早产儿的体液免疫功能,辅助治疗早产儿败血症有较好的疗效。更多还原

【Abstract】 Objective To investigate the mechanism and effect of immunoglobulin as adjuvant therapy for septicemia in premature infants. Methods Total 118 premature infants with septicemia were randomly divided into observation group( n= 58) and control group( n = 60). Both groups were given conventional anti infection treatment. The observation group was given immunoglobulin on the first day of diagnosis of septicemia,400 mg / kg per day for 3 days. The recovery time of clinical and laboratory index and the mortality rate were compared between the two groups. The serum Ig G level was compared before and after the treatment. Results The clinical recovery in the observation group was quickly as compared with the control group [( 6. 93 ± 1. 43) d vs.( 8. 47 ± 2. 13) d,P < 0. 05]. The recovery time of WBC,PLT,RP and PCT of the observation group were all earlier than those of the control group( P < 0. 05). The mortality rate of the observation group was lower than that of the control group( 5. 2% vs. 16. 7%,P < 0. 05). In the observation group,the serum Ig G level increased significantly after the treatment( P < 0. 01); in the control group,the Ig G level was not improved after the treatment( P > 0. 05). Conclusion Immunoglobulin can increase the serum Ig G level and enhance the humoral immune function of the premature infants,it is effective as adjuvant therapy for septicemia in premature infants.更多还原