【摘要】 目的 观察氢氯噻嗪联合枸橼酸钾、洛汀新分别对Dent病高钙尿症、蛋白尿的治疗效果。方法2014年1月-2015年12月于北京大学第一医院收治Dent病患儿8例,明确诊断后给予氢氯噻嗪联合枸橼酸钾治疗,其中6例同时给予洛汀新治疗,监测患儿尿钙/肌酐、24h尿钙、尿蛋白/肌酐、肾早期损伤、尿蛋白电泳、尿蛋白定量、肾脏钙化动态变化,以及肾功能、电解质的变化情况。结果8例患儿经氢氯噻嗪联合枸橼酸钾治疗后,尿钙/肌酐和24h尿钙均明显下降(P<0.001),治疗前后差异有统计学意义,其中6例(75%)恢复正常,随访最长18个月,无明显低钾血症,肾脏B超未见钙化。其中6例接受洛汀新治疗的患儿,治疗3~6个月后尿蛋白定量无明显变化(P>0.05)。结论 氢氯噻嗪联合枸橼酸钾治疗Dent病,可以有效控制高钙尿症,而洛汀新对于Dent病的蛋白尿则无治疗效果。更多还原

【Abstract】 Objective To observe the treatment effects of dihydrochlorothiazide and lotensin on hypercalciuria and proteinuria in Dent disease.Methods Dihydrochlorothiazide and potassium citrate were given to 8 cases of Dent disease following the diagnosis;lotensin was giver to 6 of the 8 cases.The ratio of urinary calcium to creatinine,quantitative test of24 h urinary calcium and protein,early injury index of kidney,urine protein electrophoresis,renal function,and electrolytes were monitored.Results The ratio of urinary calcium to creatinine and urinary calcium quantity decreased significantly after the treatment(P <0.001),and returned to normal in 6 cases(75%),with a follow-up period of 18 months.No change in urinary protein was observed in the 6 cases treated with lotensin for 3 to 6 months(P > 0.05).Conclusion Dihydrochlorothiazide and potassium citrate could effectively control hypercalciuria while lotensin showed no treatment effects on the proteinuria in Dent disease.更多还原