【摘要】 目的 探讨非肿块型乳腺癌的MRI表现与人类表皮生长因子受体2(HER-2)表达的相关性。方法 收集经病理证实的乳腺癌74例,术前MRI动态增强表现为非肿块样强化。使用免疫组化染色测定HER-2的表达情况;应用χ~2检验、Fisher确切概率法及Spearman秩相关分析病灶的形态学特征、动态增强参数及表观扩散系数(ADC)值与HER-2表达的相关性。结果 肿瘤大小与HER-2阳性表达呈正相关(r=0.341,P=0.003);ADC值与HER-2阳性表达呈正相关(r=0.317,P=0.006);峰值时间与HER-2阳性表达呈负相关(r=-0.244,P=0.036);而病灶分布特征、内在强化方式及时间-信号强度曲线类型与HER-2表达均无明显相关性(P值均>0.05)。结论 肿瘤大小、峰值时间及ADC值与HER-2的表达有一定的相关性,可间接为非肿块型乳腺癌的临床治疗方案选择及预后评估提供参考依据。更多还原

【Abstract】 Objective To investigate the association of MRI features with HER-2 expression in non-mass-like breast carcinoma.Methods 74 patients with breast cancers diagnosed by pathology underwent MRI prior to surgery,and all lesions were non-mass-like enhancement on dynamic contrast-enhanced MRI.The expression of HER-2 in tumor tissue was detected by immunohistochemical staining.Chisquare test,Fisher’s exact test and spearman rank correlation were used to evaluate the correlations between the morphological characteristics,dynamic enhanced MR parameters,ADC value and HER-2 expression.Results The tumor size was correlated positively with the expression degree of HER-2(r=0.341,P=0.003).The ADC value was also correlated positively with the positive expression degree of HER-2(r=0.317,P=0.006).However,the time to peak was correlated negatively with that(r=-0.244,P=0.036).No significant correlations between the distribution/internal enhancement manner,the type of time signal intensity curve and HER-2 expression were found(all P>0.05).Conclusion Tumor size,time to peak and ADC value are correlated with the expression of HER-2 in nonmass-like breast carcinoma,which is helpful for the treatment plan and prognosis evaluation for this cancer.更多还原