【摘要】 目的 探讨CT灌注成像在兔肝VX2肿瘤射频消融（RFA）后残癌诊断中的应用价值。方法 制备兔肝VX2肿瘤模型，在进行射频不完全消融治疗后第3、7、14、21天行CT灌注成像检查，然后处死模型兔，进行病理检查对照，进行统计学分析。结果 术后7 d内各灌注参数无统计学差异（P均>0.05）。术后第14天时炎症反应带的血流量（BF）、表面通透性（PMB）的均值分别为（32.37±3.30） mL·min^-1·100 g^-1、（16.35±2.86）mL·min^-1·100 g^-1,残癌的对应参数均值分别为（60.77±8.25） mL·min^-1·100 g^-1、（33.13±6.29）mL·min^-1·100 g^-1,2组的BF比较有显著差异（t=9.31,P=0.01）,PMB比较有显著差异（t=9.12,P=0.00）;其他参数均值差异无统计学意义（P>0.05）。术后21 d 2组的BF、血容量（BV）、PMB、肝动脉灌注量（ALP）、肝动脉灌注指数（HPI）比较P<0.05,统计学有差异。门脉灌注量（PVP）均值差异无统计学意义（P>0.05）。结论 CT灌注成像能为RFA术后提供有价值的血流动力学信息，有助于兔肝VX2肿瘤RFA治疗后残癌的早期诊断。更多还原

【Abstract】 Objective To evaluate the value of CT perfusion imaging in distinguishing residual tumor from inflammation after radiofrequency ablation(RFA) in hepatic VX2 carcinoma in rabbits.Methods Twenty-eight hepatocellular carcinoma models of New Zealand rabbits were established by implanting VX2 tumor fragments into liver.CT perfusion imaging were performed at day 3(n=6),1-week(n=6),2-week(n=6) and 3-week(n=6) after incomplete RFA in rabbits with hepatic VX2 tumors,and parameters of the lesions were measured.The pathologic specimens were sectioned in the same plane as CT imaging.Results Perfusion parameters had no obvious differences between the residual tumor and the inflammation within 7d.The CT perfusion parameters on the 14th day after incomplete radiofrequency ablation:blood flow(BF)(t=9.31,P=0.01) and permeability(PMB)(t=9.12,P=0.00) of the residual tumor were higher than those of inflammation.Conclusion Perfusion CT appears to be helpful in early distinguishing residual tumor from inflammation after radiofrequency ablation.更多还原