【摘要】 目的 评价MRI扩散加权成像(DWI)联合肝纤四项对肝纤维化评价的准确性。方法 将弥漫性肝病行腹部MRI检查(包括DWI)的患者30例作为研究对象。依炎症活动度(G)、纤维化程度(S)分级，将患者分为G0S0期、G1(S1～S2)期、G2(S1～S3)期、G3(S2～S4)期和G4S4期，分析扩散敏感系数(b值)分别为600 s/mm~2和800 s/mm~2时，不同病理分期患者表观扩散系数(ADC)值的变化；同时检测患者血清中透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(CⅣ)和层黏连蛋白(LN)的变化，结合ADC值进行分析。结果 随肝纤维化程度加重，ADC值依次降低；随ADC值的变化，血清肝纤四项指标水平也呈现不同的变化。结论 ADC值联合血清肝纤维化指标能够准确评估肝纤维化分期。更多还原

【Abstract】 Objective To evaluate the diagnostic efficacy of diffusion-weighted imaging(DWI) combined with the serum markers of liver fibrosis for liver fibrosis.Methods Thirty patients with diffuse hepatic disease were performed MRI and DWI using b values of 600 s/mm~2 and 800 s/mm~2.According to the degree of inflammatory activity(G),fibrosis(S) classification,the patients were divided into the G0S0 period,G1(S1-S2) period,G2(S1-S3) period,G3(S2-S4) period,and G4S4 period.Analyze the ADC value of different pathological staging patients when proliferation-sensitive coefficients(b values) were 600 s/mm~2 and 800 s/mm~2.Blood samples were obtained after MR examination to analyze the serum markers of liver fibrosis including hyaluronic acid(HA),procollagen type Ⅲ(PC Ⅲ),type Ⅳ collagen(C-Ⅳ) and laminin(LN).Results With the aggravation of liver fibrosis,the ADC values were decreased.The serous markers of liver fibrosis changed variously along with the change of the ADC values.Conclusion ADC value combined with the serum markers of liver fibrosis can evaluate stage in liver fibrosis patients accurately.更多还原