【摘要】 采用GC-MS法测定小鼠灌胃1,8-桉叶素后不同时间点血浆中药物浓度,利用药动学软件DAS3.0计算1,8-桉叶素在小鼠体内的药代动力学参数。结果显示:1,8-桉叶素在0.5⁸ mg/L范围内,浓度与峰面积比值呈良好的线性关系。血药浓度数据经药动学软件DAS3.0处理后,C_max为17.46 mg/L,tmax为10 min,t1/2为155.70 min。GC-MS法测定1,8-桉叶素具有快速、准确和灵敏度高的特点,药代动力学参数可为1,8-桉叶素体内抗菌治疗作用研究提供理论依据。更多还原

【Abstract】 This paper aims to determine the concentration of 1,8-cineole in mouse plasma at different time-points by GC-MS after a separate gavage with moderate dose of eucalyptus oil and to calculate the pharmacokinetic parameters in mouse plasma with pharmacokinetic software DAS3.0. After the study, the ratio of concentration and peak area shows a good linear relationship within the concentration range of 0.5-8 mg/L. After the concentration data was treated with DAS3.0,it reveals that Cmaxis 17.46 mg/L,tmaxis 10 min,t1/2is 155.70 min. This method is rapid, accurate and highly sensitive. The pharmacokinetic parameters can be used as theoretical support for in-vivo antibacterial treatment of 1,8-cineole.更多还原