【摘要】 目的探讨血浆纤维蛋白原水平与肺癌临床病理特征及预后的相关性。方法回顾性分析120例初治肺癌患者的临床病理资料,设为观察组,另选取100例同期健康体检人群为对照组。比较两组血浆纤维蛋白原(FIB)及D-二聚体(DD)水平,同时分析观察组患者FIB及DD水平与其病理特征的关系,并统计观察组患者生存期与FIB及DD水平的相关性。结果经研究发现,观察组患者FIB及DD水平明显较对照组高,P<0.05;观察组患者FIB及DD水平与肿瘤大小、病理类型及临床分期等无明显关联,P>0.05。观察组患者生存期与FIB及DD表达水平呈负相关性,P<0.05。结论密切关注肺癌患者FIB及DD水平,并加强抗凝治疗,从而对改善其预后具有重要价值。更多还原

【Abstract】 Objective To study the correlation plasma fibrinogen( FIB) levels and clinical features and prognosis of lung cancer.Methods A retrospective analysis of clinical data of 120 cases of newly diagnosed lung cancer patients( observation group) were conducted,and 100 cases of healthy people were the control group.FIB and D-dimer( DD) levels of the 2 groups were compared,and the relationship between FIB and DD levels and pathological features of the observation group was analyzed,and correlation between survival and FIB and DD levels were observed.Results The study found that FIB and DD levels in the observation group was significantly higher than that of the control group,P < 0.05; FIB and DD levels in the observation group had no obvious correlation with tumor size,pathological type and clinical stage,P > 0.05.Survival of patients in the observation group were negatively correlated with FIB and DD levels,P < 0.05.Conclusion Close attention should be paid to FIB and DD levels in lung cancer,and strengthen the anticoagulant therapy has a significant value in improving the prognosis.更多还原