【摘要】 目的探讨氢吗啡酮微创给药治疗癌痛的安全性及效果。方法选取需行止痛治疗的患者作为研究对象,随机分组,对照组常规止痛,实验1组在常规基础上采取微创给药方式,以静脉镇痛泵予盐酸氢吗啡酮0.3 mg/h,实验2组在常规基础上予盐酸氢吗啡酮2 mg每30 min一次静脉注射。对入组患者不同时间VSA、Ramesay评分、不良反应、止痛效果进行比较。结果实验1组术后6 h、12 h、24 h、48 h的VSA均低于对照组,且低于实验2组;实验2组在各时间段的VSA低于对照组,差异有统计学意义(P<0.05)。各组患者的Ramesay评分差异无统计学意义(P>0.05)。实验1组患者出现头晕1例,嗜睡1例,呕吐1例,皮肤瘙痒1例,尿潴留1例,总发生率为16.7%,实验2组不良反应发生率33.3%,对照组为16.7%,实验1组低于实验2组,差异有统计学意义(P<0.05)。实验1组止痛优良率86.7%,实验2组为53.3%,对照组仅为33.3%,实验1组高于实验2组及对照组,差异有统计学意义(P<0.05)。结论采用氢吗啡酮微创给药治疗癌痛的镇痛、镇静效果好,不良反应发生率低,安全性好。更多还原

【Abstract】 Objective To study the efficacy and safety of hydrogen morphine ketone minimally invasive for patients with cancer pain.Methods Lung cancer patients required pain treatment were selected as the research object,the control group received conventional analgesic,the experimental group 1 on the basis of conventional minor-injury received intravenous analgesia pump of hydrogen morphine hydrochloride ketone 0.3 mg/h,the experimental group 2 on the basis of routine received hydrogen morphine hydrochloride ketone 2 mg q30 min intravenous injection.VSA,Ramesay score,adverse reactions,and the analgesic effects at different time were compared.Results VSA of the experiment group 1 after 6 h,12 h,24 h,48 h were lower than those of the control group and the experiment group 2,VSA in each period of the experiment group2 were lower than that of the control group,the difference was statistically significant(P<0.05); There had no statistical difference in Ramesay rating(P>0.05); In the experiment group 1,there had dizziness in 1 case,sleepiness 1 case,vomiting 1 case,itchy skin 1 case,urinary retention 1case,total rate was 16.7%,the experimental group 2 incidence of adverse reactions was 33.3%,the control group was 16.7%,the experiment group 1 was lower than the experimental group 2,the difference was statistically significant(P<0.05); Pain relieve rate in the experiment group 1 was 86.7%,the experimental group 2 was 53.3%,the control group was 33.3%,the experiment group 1 was higher than the experimental group 2 and the control group,the difference was statistically significant(P<0.05).Conclusion Hydrogen morphine ketone minimally invasive medication has good analgesic and sedative effect,with low incidence of adverse reactions and good safety.更多还原