【摘要】 目的探讨唑来膦酸联合化疗治疗肺癌骨转移的疗效,为临床治疗提供参考。方法选取肺癌骨转移患者86例,采用随机数字表法分为观察组和对照组43例。两组患者均应用紫杉醇(150 mg/m~2)加顺铂(80 mg/m~2)联合化疗,21 d为1个周期,共3个周期。观察组在化疗的基础上增加唑来膦酸治疗,每4周重复一次,连续使用3次。结果观察组患者疼痛缓解总有效率为(86.0%),显著高于对照组(51.2%)(P<0.05)。观察组患者治疗后活动能力恢复总有效率为(79.1)%,显著高于对照组(48.8%)(P<0.05)。观察组骨病灶修复的有效率为(60.5%),显著优于对照组(44.2%)(P<0.05)。观察组患者生活质量的改善率为(93.0%),显著高于对照组(79.1%)(P<0.05)。两组患者不良反应发生率比较无显著差异(P>0.05)。结论唑来膦酸联合化疗治疗肺癌骨转移疗效显著,可明显缓解患者骨痛症状,提高患者的活动能力和生活质量。更多还原

【Abstract】 Objective To investigate the efficacy of zoledronic acid and chemotherapy for bone metastasis of lung cancer,to provide reference for clinical treatment.Methods 86 patients with lung cancer bone metastasis were randomly divided into the observation group and the control group,each with 43 cases.Both groups received paclitaxel(150 mg/m~2) plus cisplatin(80 mg/m~2) combined with chemotherapy,21 d for a period of 3 cycles.On the basis of chemotherapy,the observation group was treated with zelodronic acid 4 times per week for 3 weeks.Results The total effective rate of pain relief in the observation group was significantly higher than that of the control group(86.0% vs 51.2%)(P<0.05).The total effective rate of recovery activities of the observation group after treatment was significantly higher than that of the control group(79.1% vs 48.8%)(P<0.05).The effective rate of bone lesion repair of the observation group was significantly higher than that of the control group(60.5% vs 44.2%)(P<0.05).The improvement rate of life quality in the observation group was higher than that of the control group(93.0% vs 79.1%)(P<0.05).There was no significant difference in adverse reactions between the 2 groups(P>0.05).Conclusion Zoledronate acid combined with chemotherapy in the treatment of bone metastasis of lung cancer has a significant effect,it can relieve symptoms of patients with bone pain and improve the activity ability and quality of life of the patients.更多还原