【摘要】 目的研究肿瘤标记物α-甲胎蛋白(AFP)、甲胎蛋白抑制体(AFP-L3)及脱-γ-羧基-凝血酶原(DCP)对肝细胞癌(HCC)患者行肝切除术后复发的预测价值。方法收集行HCC肿瘤病灶根治性切除术的患者58例,考察患者的基本情况以及血清DCP、AFP及AFP-L3水平与HCC术后复发率的关系。结果术后血清AFP、DCP及AFP-L3水平均升高的患者复发率均明显提高。多因素分析结果显示:HCC患者肝切除术前血清AFP、DCP及AFP-L3联合检测与术后复发率无相关性[1.13(0.804~1.479),P>0.05],而术后血清AFP、DCP及AFP-L3联合检测则是影响术后复发率的独立因素[3.68(1.711~3.798),P<0.01]。结论血清中肿瘤标记物AFP、DCP及AFP-L3联合检测对HCC患者肝切除术后复发监测敏感有效,为HCC术后疗效评估及追踪复查提供了一条新途径。更多还原

【Abstract】 Objective To study the predictive value of combined detection of 3 tumor markers( AFP,AFP-L3 and DCP) for relapse after resection of hepatocellular carcinoma( HCC). Methods 58 HCC patients treated with radical resection were collected,and the relationship between serum DCP,AFP and AFP-L3 levels and HCC recurrence rate was detected. Results The postoperative serum AFP,DCP and AFP-L3 levels were elevated and the relapse rate in patients improved significantly. Multivariate analysis showed that joint detection of serum AFP,DCP and AFP-L3 levels before liver resection had no correlation with recurrence rate[1. 13( 0. 804 ~ 1. 479),P > 0. 05]. Joint detection of serum AFP,DCP and AFP-L3 levels after liver resection was an independent factor affecting recurrence rate [3. 68( 1. 711 ~ 3. 798),P < 0. 01]. Conclusion The combined detection of serum tumor markers AFP,DCP and AFP-L3 is highly sensitive and effective in monitoring the recurrence rate of HCC patients after liver resection. It can provide a new way to track and evaluate postoperative efficac.更多还原