【摘要】 目的观察康莱特配合放疗对非小细胞肺癌的疗效及患者免疫功能的影响。方法将120例部分晚期非小细胞肺癌患者平均随机分为观察组和对照组。对照组单一采用放疗药物治疗,疗程为2个月。观察组在放疗的基础上配合应用康莱特注射液100 ml静脉注射,1次/天,从化疗前1天开始,1个月为1个疗程,共治疗2个疗程。分析2组患者的有效率,并测定治疗前后患者免疫细胞的变化情况。结果观察组与对照组相比,总有效率及疾病控制率均明显增高,不良反应发生率明显降低。观察组CD3+、CD4+、CD8+、CD4+/CD8+及NKT细胞活性均显著优于对照组,免疫球蛋白水平也高于对照组,P均<0.05。结论康莱特配合放射治疗对NSCLC患者存活率、缓解率的提高有重大意义,在改善患者生活质量的同时具有放射增敏作用,有一定临床使用价值。更多还原

【Abstract】 Objective To observe the curative effect of Kanglaite combined with radiotherapy for non-small cell lung cancer( NSCLC) and its influence on immune function. Methods 120 cases of NSCLC were randomly divided into the observation group and the control group. The control group received radiotherapy-drug therapy for 2 months. The observation group were given radiotherapy and 100 m L Kanglaite intravenous drip once per day,the course was 2 months. Effective rate of the 2 groups were analyzed and the change of immune cell were measured. Results The total effective rate and disease control rate in the observation group was higher than that of the control group. The incidence rates of the observation group were markedly lower than that of the control group. CD3 + 、CD4 + 、CD8 + 、CD4 + / CD8 + and NKT cells activity of the observation group were superior to the control group. The level of immune globulin of the observation group was higher than that of the control group( P < 0. 05).Conclusion Kanglaite combined with radiotherapy for NSCLC patients can increase the survival rate and remission rate,and improve the quality of life. It has radiotherapy sensitization effect and certain clinical value.更多还原