Objective:To explore whether the receptor for advanced glycation endproducts( RAGE) is associated with the occurrence of endometrial carcinoma and further analyze the possible mechanism.Methods:The endometrial carcinoma specimens were collected.The RAGE expression and microvessel density in endometrial carcinoma tissues were detected by immunohistochemistry,and their relation was analyzed.RAGE protein expression levels in the non-cancerized endometrium and endometrial carcinoma tissues were analyzed with th...
Modern Oncology 2016,24(17):2670-2673子宫内膜癌是发生于子宫内膜的一组上皮性恶性肿瘤,以来源于子宫内膜腺体的腺癌最常见[1]。近年来的研究发现,肥胖、高血压、糖尿病等一系列代谢性疾病与子宫内膜癌的发生明显相关[2,3]。其中,糖尿病是目前公认的子宫内膜癌发病的高危因?