Ovarian cancer is closely associated with the gene instability and abnormal cell behavior caused by the accumulation of DNA damage. The most important pathways among the DNA double-strand break repair pathways is HRR,NHEJ and alt-NHEJ,which are capable of fast and accurate repair and therefore is crucial to the gene stability and is significant for the gene diagnosis,gene therapy and molecular study of ovarian cancer.
【更新日期】
2016-02-23
【分类号】
R737.31
【正文快照】
Modern Oncology 2016,24(04):0657-0659卵巢癌为一种常见的侵袭性疾病,是女性第五大致死性恶性肿瘤,患病风险接近1.4%,每年有大约20万女性被确诊[1],因其起病隐匿、缺乏早期诊断指标,多数确诊时已属晚期。近年来大量研究证实DNA损伤将引起基因的不稳定性,影响遗传物质的正常传
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