Objective:To investigate the efficacy of alternate administer of sunitinib and sorafenib in the treatment of metastatic renal cell carcinoma(mRCC).Methods:We report a case of mRCC treated with alternate administer of sunitinib and sorafenib,and review the literatures.Results:The patient was treated first-line therapy with sunitinib,time to progress(TTP)was 6 months.Second-line therapy with sorafenib,TTP:6 months.Regulate dose regimen of sunitinib(37.5mg once-daily,continuous administer)in patient who had fa...