【摘要】 目的:探讨肠内营养制剂对中晚期肺癌合并肺炎患者炎症因子的影响。方法:86例肺癌合并肺炎患者,分为肠内营养组(EN组)(43例)和对照组(47例)。EN组给予肠内营养制剂(百普素)200~300g/d+普通饮食,连续服用14d以上;对照组进食普通食物。两组应用抗生素级别相同。检测患者治疗前、治疗后3d,7d血清中的炎症因子指标和血液学指标,记录抗生素应用时间及患者治疗过程中呕吐、腹泻等不良反应。结果:治疗后第3天EN组的白介素-6(IL-6)和α-1酸性糖蛋白(AAG)水平均低于对照组(P<0.05),治疗后第7天EN组的IL-6、肿瘤坏死因子-α(TNF-α)和AAG水平均低于对照组(P<0.05);治疗后第7天前白蛋白(PA)、血红蛋白(HGB)、白蛋白(ALB)水平均高于对照组(P<0.05),其余指标比较无统计学差异(P>0.05)。EN组发生腹胀、腹泻不良反应5例,对照组6例,两组的不良反应发生率比较差异无统计学意义(P>0.05)。抗生素应用时间:EN组6.41±1.28d,少于对照组的9.32±2.25d(P<0.05)。结论:肺癌合并肺炎患者治疗过程中应用肠内营养制剂能提高抗生素治疗肺部感染的疗效,且耐受性良好。更多还原

【Abstract】 Objective:To investigate the effects of enteral nutrition on blood and inflammation factor levels in patients with lung cancer complicated pulmonary infection.Methods:86 cases of lung cancer complicated with pulmonary infection admitted were randomly divided into enteral nutrition(EN)groups(43cases)and control group(47cases).EN group before and after treatment were given enteral nutrition(Nutricia)as enteral nutrition preparation 200~300 g/d+ ordinary diet,were continuously taking more than 14 days;control group fed on ordinary diet and the same level of two groups of antibiotic drugs.3 days of treatment were measured before and after treatment,inflammation index 7days in serum and hematological indexes.Record the application time of antibiotics and the adverse reactions such as vomiting,diarrhea and so on during the course of treatment.Results:The level of treatment after 3 days in the EN group of interleukin-6(IL-6)and alpha-1 acid glycoprotein(AAG)were lower than those in the control group(P<0.05),after treatment on day 7 in the EN group IL-6,tumor necrosis factor alpha(TNF alpha)and AAG levels were lower than the control group(P<0.05),treatment after 7days prealbumin(PA),hemoglobin(HGB),albumin(ALB)levels were higher than in the control group(P<0.05).Difference in other indexes had no statistical significance(P>0.05).During the period of enteral nutrition support,there were 3 cases of abdominal distension in EN group,2 cases of diarrhea,4 of abdominal distension and 2 of diarrhea in the control group.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The time of antibiotic application in EN group was 6.41±1.28 days,the control group was 9.32±2.25 days,the difference between the two groups was statistically significant(P<0.05).Conclusion:The application of nutritional agents in the treatment of lung cancer complicated with pneumonia can improve the curative effect of antibiotics in the treatment of pulmonary infection,and is well tolerated.更多还原