【摘要】 目的:探讨酸柏栀油软胶囊抗氧化作用。方法:将60只SD大鼠随机分为正常对照组、模型对照组、高、中、低酸柏栀软胶囊组和辛伐他汀组。对照组正常饮食,其他组高脂饮食,4周后,眼眶采血全自动生化分析仪测定血清中甘油三酯(TG)、总胆固醇(CH)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平。高脂血症大鼠模型建立后,对照组不做处理,其他组均在每天上午9:00按1ml/100g剂量灌胃:模型对照组给予生理盐水,阳性对照组给予辛伐他汀(0.3mg/100g),高剂量组给予酸柏栀油软胶囊(0.45g/100g),中剂量组给予酸柏栀油软胶囊(0.18g/100g),低剂量组给予酸柏栀油软胶囊(0.072g/100g)。5周后,水合氯醛腹腔麻醉,腹主动脉采血测定血浆中TG、CH、HDL、LDL及总超氧化物歧化酶(T-SOD)水平。结果:高脂饮食4周后,高脂饮食大鼠血浆CH、HDL、LDL水平高于对照组,TG水平低于对照组(P<0.05)。干预5周后,酸柏栀油软胶囊均可降低高脂血症大鼠血清TC、升高血清T-SOD(P<0.01);高剂量组降低LDL-C和TG水平(P<0.05)。结论:酸柏栀油软胶囊具有降低高脂血症大鼠血脂和升高高脂血症大鼠血清总超氧化物歧化酶作用。更多还原

【Abstract】 Objective:To investigate the antioxidant effects of soft capsule of compound oil of jujube,arboruitae,and gardenia.Methods:The 60 SD rats were randomly assigned to normal control group,model control group,high,medium and low SCCOJAG group and simvastatin group.A normal diet was given to the control group and a high fat diet was given to other groups.After 4weeks,the level of triglyceride(TG),total cholesterol(TC),high density lipoprotein(HDL)and low density lipoprotein(LDL)in serum were determined by the automatic biochemical analyzer for orbital blood sampling.After the establishment of the model of hyperlipidemia rats,other groups were administered in the dose of 1ml/100 g every 9:00a.m.according to the gavage method except for the control group;model control group was given normal saline,the positive control group received simvastatin(0.3mg/100g),high dose group given SCCOJAG(0.45g/100g),middle dose group given acid SCCOJAG 0.18g/100 g,low dose group given SCCOJAG 0.072g/100 g.After 5weeks,the abdomen was anaesthetized with chloral hydrate,the abdominal aortic blood sampling was collected to determine the levels of plasma TG,TC,HDL,LDL and total superoxide dismutase(T-SOD).Results:After high fat diet for 4weeks,plasma TC,HDL and LDL levels of the rats with high fat diet were higher than those in the control group(P<0.05),and TG levels were lower than those in the control group(P<0.05).After 5 weeks’ intervention,SCCOJAG could reduce serum TC of the rats with hyperlipidemia,elevated serum levels of T-SOD(P< 0.01);High dose group decreased low density lipoprotein cholesterol(LDL-C)and TG levels(P< 0.05).Conclusion:SCCOJAG can reduce the blood lipid of hyperlipidemia rats and elevated serum TSOD in rats with hyperlipidemia..更多还原