【摘要】 目的 探讨叉头框蛋白J2(forkhead box J2,Foxj2)在非小细胞肺癌(non-small cell lung cancer,NSCLC)患者癌组织中的表达及其临床意义。方法 收集50例NSCLC患者手术切除肺癌组织标本,用免疫印迹法(western blot)和免疫组化法检测Foxj2在癌组织和癌旁组织中的表达。结果 western blot显示Foxj2在癌旁组织中的表达高于癌组织,两组间差异具有统计学意义(P<0.05);免疫组化结果表明Foxj2在癌旁组织中的阳性细胞数明显高于癌组织,且无淋巴结转移组Foxj2的表达强度高于有淋巴结转移组,两组间差异具有统计学意义(P<0.01)。结论 Foxj2参与NSCLC的发生发展过程,并且可能与NSCLC淋巴结转移有关。更多还原

【Abstract】 Objective To evaluate the expressions and its clinical significance of Foxj2 in non-small cell lung cancer(NSCLC)patients.Methods Fifty cancer tissues from patients who underwentsurgery were collected.Western blot and immunohistochemical methods were used to detect the expressions of Foxj2.Results Results of western blot showed that Foxj2 expression in lung cancer tissue was significantly lower than adjacent tissues.The difference between the two groups was statistically significant(P<0.05).Immunohistoehemical results showed that the number of Foxj2-positive cells in adjacent tissues was significantly higher than that in cancer tissues,and the expression of Foxj2 in non-lymphatic node metastasis group was higher than that in lymphatic node metastasis.The difference between the two groups was statistically significant(P <0.01).Conclusion The expressions and location of Foxj2 was related to the lymphatic node metastasis of lung cancer.This phenomenon indicates that Foxj2 may play an important role in the development of lung cancer.更多还原