【摘要】 长链非编码RNA(long non-coding RNA,lncRNA)在多个水平参与调节机体的各项基础生物进程,其功能紊乱常伴随疾病的发生。鉴定lncRNA的生物学功能已成为近年来的研究热点。然而,目前从各种真核生物高通量测序中鉴定的几十万个lncRNA中,只有极少数的功能已被实验验证,这对于该领域的深入研究是个巨大的挑战。因此,许多科研机构都建立了lncRNA数据库,并且持续周期性更新,这为研究者共享、注释和分析lncRNA功能提供了十分有效的工具。本文从lncRNA原始资源整合、筛选、鉴定及功能分析和lncRNA与人类疾病等4个方面介绍各lncRNA数据库资源的最新特征和应用范围。这为研究者在选择不同数据库资源进行lncRNA鉴定和分析时提供参考。更多还原

【Abstract】 As a key component of cellular regulatory machinery at the transcriptional, posttranscriptional,and epigenetic levels,long non-coding RNAs( lncRNAs) participate in almost every basic biological process. Dysfunction of lncRNA often accompanies a vareity of diseases. Clarification of the biological functions of lncRNAs has become a research focus in recent years. However,the sheer magnitude of vast amounts of lncRNA sequencing data from a myriad of eukaryotes that has been produced by high-throughput sequencing techniques actually represents a significant challenge in this field. Accordingly,a number of lncRNA databases have been established. These are regularly updated by scientific research institutions and provide useful tools for researchers to share,annotate,and analyze the functions of lncRNAs. In this review,we introduce the latest features and applications of various lncRNA database resources in four sections,including: original resource integration,selection and identification,functional analysis,and association of lncRNAs with human diseases. By familiarizing investigators with the strengths and features of these various databases,our review should help expediate the identification and analysis of important lncRNA information.更多还原