【摘要】 随着组织工程学的发展,利用间充质干细胞(mesenchymal stem cells,MSCs)定向分化为软骨细胞,用于治疗骨性关节炎、关节创伤等因素造成的软骨缺损的研究方兴未艾。透明质酸(hyaluronic acid,HA)是一种酸性多糖类生物大分子,亦是软骨基质的主要成分之一。由于其优良的生物相容性、可降解等特性,HA已成为优良的天然生物材料,其作为支架材料应用于软骨缺损修复已有一段历史。近年来又发现,HA除作为载体支架材料外,还可作为调节因子应用于MSCs向软骨细胞分化。以下将对近年来利用HA应用于MSCs向软骨细胞分化的研究进行总结,旨在为以MSCs为基础的组织工程化软骨的临床应用奠定基础。更多还原

【Abstract】 With the development of tissue engineering,the use of mesenchymal stems cells( MSCs)differentiation into chondrocytes,to treat the articular cartilage injury,induced by osteoarthritis or joint trauma,has been attracting more and more attention.Hyaluronic acid( HA),a acidic polysaccharide macromolecules,is one of the main components of cartilage matrix and possess some characteristics such as biocompatibility and biodegradability,and can be used as excellent natural biological material.It has been a long history of HA which is used as scaffold material on repair cartilage defect.In recent years,some studies found that HA not only could be used as scaffold material,but also a regulator factor,applied to differentiate into cartilage.The application of MSCs differentiating into cartilage cells combined with HA in recent years were outlined.It will provide new idea for the clinical application of tissue-engineered cartilage on the basis of the MSCs.更多还原