【摘要】 本文旨在研究注意缺陷多动障碍(ADHD)患儿和正常儿童事件相关电位差异,为ADHD的诊断提供科学依据。用精神障碍的诊断与统计手册(DSM-Ⅳ)诊断标准确定ADHD组8例,对照组8例。对所有对象进行改进型视觉持续性行为测试,包括Go和NoGo两个条件。采用高密度脑电采集仪记录脑电用于后续分析,分析P2-N2峰峰值以及频谱在11Hz左右的峰值,找出差异进行检验。实验结果表明:1Go条件下ADHD组P2-N2峰峰值显著低于对照组(P<0.05);NoGo条件下差异无统计学意义。2在NoGo条件下,ADHD组在11 Hz左右的频谱峰值显著低于对照组(P<0.05),而在Go条件下差异无统计学意义。因此,ADHD患儿存在一定的认知功能障碍。临床上可用P2-N2峰峰值、频谱在11Hz左右峰值作为评价ADHD患儿认知功能的脑电生理指标,为ADHD的早期诊断和治疗提供客观依据。更多还原

【Abstract】 This study aims to explore the differences of event-related potential(ERP)between attention deficit hyperactivity disorder(ADHD)and normal children,so that these differences provide scientific basis for the diagnosis of ADHD.Eight children were identified to be ADHD group by the diagnostic criteria of DSM-IV(diagnostic and statistical manual of mental disorders-IV),and the control group also consisted of 8normal children.Modified visualcontinuous performance test(CPT)was used as the experiment paradigm.The experiment included two major conditions,i.e.Go and NoGo.All the 16 subjects participated in the study.A high density EEG acquisition instrument was used to record the EEG signal and processed these EEG data by means of ERP and spectrum analysis.P2-N2peak-peak value and spectral peak around 11 Hz were analyzed between ADHD subjects and those in the control group,and then statistical tests were applied to these two groups.Results showed that:1 Under the condition of Go,ADHD group had a significant lower P2-N2peak-peak value than the values in the control group(P<0.05);but under the condition of NoGo there was no significant difference in between.2 Compared with the control group,the ADHD group had significant lower spectral amplitude around 11 Hz under the condition of NoGo(P<0.05).However,under the condition of Go the difference was insignificant.In conclusion,there is certain cognitive dysfunction in ADHD children.P2-N2peak-peak value and spectral peak around 11 Hz could be considered as clinical evaluation indexes of ADHD children′s cognitive function.These two objective indexes provide an early diagnosis and effective treatment of ADHD.更多还原