【摘要】 目的:探讨ERα-29位基因多态性与HBV相关原发性肝癌(PHC)易感性的关系。方法:通过聚合酶链反应-限制性片段长度多态性法检测我院100例HBV相关原发性肝癌患者(PHC组)与95例同期健康体检者(对照组)的ERα-29位基因多态性并对两组间各等位基因、基因型频率进行比较。结果:PHC组ERα-29位基因的TT、TC和CC基因型分别有31例(31.00%)、45例(45.00%)和24例(24.00%),T与C等位基因频率分别为53.50%和46.50%,对照组ERα-29位基因的TT、TC和CC型基因型分别有11例(11.58%)、39例(41.05%)和45例(47.37%),T与C等位基因频率分别为32.11%和67.89%,两组间基因型分布、等位基因频率差异均具有统计学意义(P<0.05);T等位基因发生PHC的风险是C等位基因的2.43倍(OR=2.43,95%CI:1.37~4.32)。结论:ERα-29位基因与HBV相关原发性肝癌易感性有关,其中T等位基因可增加发生风险。更多还原

【Abstract】 Objective:To explore the relationship between ERα-29 gene polymorphisms and HBV-related hepatocellular carcinoma.Methods:polymerase chain reaction-restriction fragment length polymorphism was conducted to detect the ERα-29 gene polymorphisms of 100 HBV-related hepatocellular carcinoma patients and 95 healthy people.The alleles and genotypes between these two groups were compared.Results:The numbers of TT,TC and CC genotype of ERα-29 gene in the PHC group were 31 cases(31.00%)、45 cases(45.00%)and 24 cases(24.00%),while the rate of T and C allele were 53.50% and 46.50% respectively.The numbers of TT,TC and CC genotype of ERα-29 gene in the control group were 11 cases(11.58%),39 cases(41.05%)and 45cases(47.37%),while the rate of T and C allele were 32.11% and 67.89% respectively.The rate of genotypes and alleles between these two groups all had statistical difference(P<0.05).Compared to the C allele,the incidence of PHC of T allele carrier was 2.43 times higher(OR=2.43,95%CI:1.37~4.32).Conclusion:ERα-29 has a relationship with HBV-related hepatocellular carcinoma,and the T allele carrier can increase the risk.更多还原