【摘要】 目的:探讨川穹嗪注射液对血浆TGF-β1水平的影响及对放射性肺损伤的预防作用。方法:随机选取120例胸部肿瘤放疗患者分为观察组与对照组,所有研究对象给予三维适形放射治疗,观察组在放疗期间川芎嗪注射液每日静脉滴注1次;检测两组放疗前后血浆TGF-β1含量变化、放射性肺损伤及肺功能情况。结果:放疗后两组血浆TGF-β1均上升,观察组在放疗结束时、放疗结束后3月、6月的血浆TGF-β1含量明显低于对照组(P<0.05)(19.12±5.23)vs(26.69±5.38)ng/m L、(5.62±3.48)vs(9.64±7.82)ng/m L、(3.28±1.81)vs(7.98±5.16)ng/m L;观察组放射性肺损伤发生率低于对照组(P<0.05);观察组放疗后三月肺功能指标用力肺活量(FVC)、第1秒用力呼气容积(FEV)、肺总量(TLC)、CO弥散量(DLCO)出现明显下降的例数显著低于对照组(P<0.05)。结论:川芎嗪注射液可以降低放疗肺损伤患者的血浆TGF-β1含量,降低放射性肺炎与放射性肺纤维化的发生率,改善肺功能,无明显不良反应、安全性好,可起到较好的预防放疗后放射性肺损伤的作用。更多还原

【Abstract】 To investigate the effect of Ligustrazine Injection on plasma TGF- beta 1 level and preventive effect on radiation-induced lung injury. Methods: 120 patients with thoracic tumor radiotherapy were randomly divided into observation group and control group, 60 cases, 60 cases, all the patients were treated with three-dimensional conformal radiation therapy. The observation group was treated with ligustrazine injection 1 times daily. The plasma levels of TGF- beta 1 were detected before and after radiotherapy. The incidence of radiation induced lung injury was observed in the two groups after radiotherapy 3months and 6months. Results: The plasma levels of TGF- 1 in the two groups were increased, and the levels of TGF- in June and March were significantly lower than those in the control group(P<0.05)(19.12 ±5.23) vs(26.69 ±5.38) ng/m L,(5.62 ±3.48) vs(9.64 ±7.82) ng/m L,(3.28 ±1.81) vs(7.98 ±5.16)ng/m L. The incidence of lung injury in the observation group was significantly lower than that in the control group(FVC). The TLC,DLCO and P<0.05 were significantly lower than those in the control group(P<0.05). Conclusion: ligustrazine injection can reduce the content of TGF- beta 1 in patients with lung injury, reduce the incidence of radiation pneumonia and pulmonary fibrosis, improve lung function, no obvious adverse reactions, good safety, can play a good role in preventing radiation-induced lung injury after radiotherapy.更多还原