【摘要】 目的:揭示维药罗补甫克比日丸对糖尿病(DM)性勃起功能障碍(ED)大鼠性激素水平的影响。方法:取50只SD雄性大鼠,从中随机取7只设为正常对照(A)组,余43只行腹腔注射链尿佐菌素(STZ)制造DM动物模型,未成模者为STZ组,成模者用阿朴吗啡(APO)筛选DM性ED模型,并将其随机分为DM性ED对照组、药罗补甫克比日丸(C)组、胰岛素(D)组、联用(E)组,未成ED模者为DM(F)组,共7组。药物干预6周后,检测外周血中性激素水平。结果:正常对照(A)组、DM性ED胰岛素(D)组、DM性ED联用(E)组、STZ(G)组睾酮(T)水平显著高于DM性ED对照(B)组、DM性ED伊木萨克(C)组、DM(F)组,有显著性差异(P<0.01);正常对照(A)组、STZ(G)组促黄体生成激素(LH)水平显著低于DM性ED伊木萨克(C)组、DM性ED联用(E)组,有显著性差异(P<0.05、P<0.01);DM性ED对照(B)组、DM性ED补甫克比日丸(C)组促卵泡刺激素(FSH)水平显著低于DM性ED胰岛素(D)组、DM性ED联用(E)组,有显著性差异(P<0.01、P<0.05)。结论:维药罗补甫克比日丸可显著改善DM性ED大鼠睾酮水平,且与胰岛素联用优于单用,维药罗补甫克比日丸治疗DM性ED的作用机制可能与T、LH、FSH含量变化有关。更多还原

【Abstract】 Objective:To explore the effect of luobupukebiriwan on the serum sex hormones levels of erectile dysfunction(ED)with diabetes mellitus(DM) rats.Methods:43 Male Sprague-Dwaley rats were injected with streptozotozin(STZ) to make experimental models of DM,then injected with apomorphine(APO) in all of the DM rats to select erectile dysfunction rats models with diabetes.The 7normal rats is in the Normal(A) group,the ED rats were divided into the model(B) group,the luobupukebiriwan(C) group,the insulin(D) group,the luobupukebiriwan with insulin(E) group;the rats without erectile dysfunction were called the DM(G) group;the rats without diabetes were called the STZ(F) group.After 6 weeks,the serum sex hormones levels were detected.Results:The testosterone(T)in group A,D,E and G was higher than that of group B,C and F(P<0.01);the luteinizing hormone(LH) in group A and G was lower than that of group C and E(P<0.01,P<0.05);the follicle stimulating hormone(FSH) in group B and C was lower than that of group D and E(P<0.01,P<0.05).Conclusion:Luobupukebiriwan can significantly increase serum testosterone level of ED with DM rats,which may be related to the change of T,LH and FSH,and the effect will be better when Luobupukebiriwan is used combined with insulin rather than single-use.更多还原