【摘要】 建立了头孢克肟、月桂酰吲达帕胺、布地奈德等难溶性药物中氯离子和三氟乙酸根的阀切换-离子色谱检测方法。分离柱为IonPac AS23柱,通过考察阴离子保留情况,选择3.5 mmol/L碳酸钠+1.0 mmol/L碳酸氢钠作淋洗液,对难溶性药物中氯离子和三氟乙酸根进行了分析。在上述条件下,氯离子和三氟乙酸根能很好地分离,并在质量浓度为0.10~10.00 mg/L时与对应色谱峰面积之间的线性关系良好,检出限分别为0.006 mg/L和0.06m g/L,回收率为90%~94%。该方法简便、快速、准确,可用于实际样品的测定。更多还原

【Abstract】 A method was developed for the determination of chloride and trifluoroacetate in water-insoluble pharmaceuticals such as cefixime,lauroyl-indapamide,budesonide by valve switch-ion chromatography.Chromatographic separation was performed on an IonPac AS23 column,3.5 mmol/L sodium carbonate and 1.0 mmol/L sodium bicarbonate eluents were used.The effects of the types of column and eluent,eluent concentration of inorganic anions were investigated.The linear ranges of the method for seven anions were 0.10-10.00 mg/L,and the detection limits(S/N-3) of chloride and trifluoroacetate were 0.006 mg/L and 0.06 mg/L respectively.The recoveries of inorganic anions spiked in cefixime were between 90%and 94%.The method was successfully used in the determination of inorganic anions in real samples.更多还原