Autophagy is a highly conserved intracellular degradation system, by which cytoplasmic components including macromolecules and organelles are sequestered into a double-membrane vesicle, an autophagosome, and then delivered into lysosome, for breakdown and eventual recycling of cytoplasm-derived materials. Autophagy is essential for preimplantation development of mouse embryos. Moreover, it has been shown that autophagy participates in the regulation of the somatic reprogramming process, including i PS cell ...
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