Canonical function of aminoacyl-tRNA synthetase(aaRS) is providing materials for protein biosynthesis. Emerging evidence shows that several aaRS can be secreted as extracellular cytokines, which further regulate cellular and organismal functions, and participate in the etiology of specific diseases. The functional form of secreted aaRS could be divided into three types: the whole molecules, proteolytic fragments and disease-associated mutants. Secreted aaRS could regulate a broad range of target cells inclu...
【基金】
国家重大科学研究计划(2012CB911001)
【更新日期】
2016-06-28
【分类号】
Q55
【正文快照】
氨基酰-tR NA合成酶(aminoacyl-tR NA synthetaseaa RS)在生物体内普遍存在,是生物体正常的新陈代谢必不可缺的一类酶。它们催化氨基酸与相应的t RNA形成氨基酰-t RNA,为蛋白质的翻译提供原料[1]。氨基酰-t RNA合成酶精确地催化含三联反密码子的t RNA和对应氨基酸之间的酯化反?
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