【摘要】 目的研究骨肽注射液联合丹参酮注射液对胫骨骨折术后血清骨性标志物水平及关节功能影响。方法选择2013年3月~2015年3月期间在建德市中医院骨科接受切开复位内固定治疗的胫骨骨折患者76例,根据术后治疗方法不同随机分为观察组和对照组,观察组术后接受常规治疗联合骨肽注射液、丹参酮注射液治疗,对照组接受常规治疗。比较2组患者的手术情况、血清骨性标志物水平以及踝关节功能。结果 2组患者在手术时间、术中出血量、术后引流量3方面差异无统计学意义,观察组术后第3、7天时的VAS疼痛评分低于对照组,观察组的患肢肿胀持续时间、卧床时间短于对照组(P<0.05);术后第7天时,观察组患者血清中骨碱性磷酸酶(BALP)比例以及Ⅰ型前胶原羧基端肽(carboxyterminal propeptide of typeⅠprocollagen,PICP)、骨钙素(bone gamma-carboxyglutamic-acid-containing proteins,BGP)的含量显著高于对照组(P<0.05),总骨Ⅰ型前胶原氨基端延长肽(total procollagen type 1 amino-terminal propeptide,t PINP)含量、Ⅰ型胶原羧基端肽β特殊序列(β-isomerized C-terminal crosslinking of type I collagen,β-CTX)的含量显著低于对照组(P<0.05);观察组患者术后第3、6、12个月时的Baird-Jackson踝关节功能评分显著高于对照组(P<0.05)。结论骨肽注射液联合丹参酮注射液能够减轻术后疼痛和肿胀、调节骨代谢状态、改善踝关节功能,是胫骨骨折术后理想的治疗药物。更多还原

【Abstract】 Objective To study the effect of ossotide injection combined with tanshinone injection on postoperative levels of serum bone markers and joint function of tibia fracture. Methods 76 cases of tibia fracture patients received open reduction and internal fixation treatment in our hospital from March 2013 to March 2015 were collected and randomly divided into observation group and control group according to different postoperative treatment method. Patients in observation group received routine treatment combined with ossotide injection and tanshinone injection treatment,and patients in control group received routine treatment. Then operation condition,serum bone marker levels and ankle joint function were compared.Results The operative time,bleeding volume,postoperative drainage volume between two groups had no difference. 3 and 7 days after operation,VAS pain scores in observation group were lower than the control group( P < 0. 05),limb swelling duration and bed rest time were shorter than the control group( P < 0. 05); 7 days after operation,serum BALP proportion and PICP,BGP content of observation group were higher than those of the control group( P < 0. 05),t-PINP,β-CTX levels were lower than the control group( P < 0. 05); observation group’s Baird-Jackson ankle joint function score of3 months,6 months and 12 months after operation were higher than control group( P < 0. 05). Conclusion The ossotide injection combined with tanshinone injection could reduce postoperative pain and swelling,regulate bone metabolism,improve the function ofankle joint,which is ideal drug for the treatment of tibia fracture.更多还原