【摘要】 目的·通过观察症状性迟发型性腺功能减退(SLOH)合并勃起功能障碍(ED)患者血清生殖激素变化情况,探讨生殖激素与SLOH合并ED(SLOH/ED)的相关关系。方法·采用问卷调查的方式,经整群及年龄分层多阶段不等比例的随机抽样方法,抽取3 000例40~80岁有固定性伴侣的社区中老年男性作为研究对象。采用老年男性症状(AMS)量表评估SLOH及其严重程度,采用国际勃起功能指数问卷表-5(IIEF-5)评估勃起功能,同时检测血清总睾酮(TT)、游离睾酮(FT)、黄体生成素(LH)和性激素结合球蛋白(SHBG)水平,计算生物活性睾酮(Bio-T)水平,单因素和多因素Logistic回归分析生殖激素与SLOH/ED的相关关系。结果·共获得2 588例符合条件的完整研究资料,平均年龄(57.95±8.50)岁。930例(35.94%)男性观察到SLOH(AMS≥27)症状,其中812例(31.38%)男性同时存在ED。739例(28.56%)男性既无SLOH亦不存在ED症状。Logistic回归分析显示TT及FT水平与SLOH/ED的相关关系不明显,年龄、SHBG和Bio-T与SLOH/ED的相关关系有统计学意义(P<0.01)。结论·SHBG和Bio-T与SLOH/ED显著相关,能准确反映SLOH/ED患者的皿清生殖激素水平。更多还原

【Abstract】 Objective · To explore the correlation between reproductive hormones and symptomatic late-onset hypogonadism combined with erectile dysfunction(SLOH/ED) via observing the changes in serum reproductive hormones in patients with SLOH/ED.Methods · Questionnaire survey was used and 3 000 males aged 40 to 80 years with regular sexual partners were selected with random cluster and age-stratified multi-phase disproportionate samplings.SLOH was evaluated with the aging male symptoms(AMS) scale.ED was evaluated with the simplified international index of erectile function(IIEF-5).Serum reproductive hormones such as total testosterone(TT).free testosterone(FT),luteinizing hormone(LH),and sex hormone-binding globulin(SHBG) were examined.Bioavailable testosterone(Bio-T) was calculated.The correlation between reproductive hormones and SLOH/ED was analyzed using univariate and multivariate Logistic regression analyses.Results- The study population consisted of 2 588 eligible males with a mean age of(57.95±8.50) years.SLOH(AMS ≥ 27) was observed in 930(35.94%) males.Of them,812(31.38%) had ED.739(28.56%) had neither SLOH nor ED.Logistic regression analyses revealed that TT and FT levels were not significantly correlated with SLOH/ED.while the correlation of age,SHBG,and Bio-T with SLOH/ED was statistically significant(P<0.01).Conclusion · SHBG and Bio-T are significantly correlated with SLOH/ED and can correctly reflect reproductive hormone levels in patients with SLOH/ED.更多还原