【摘要】 目的:探讨前列腺穿刺患者前列腺癌检出率情况,并分析其与前列腺特异性抗原(prostate specific antigen,PSA)、年龄的相关性。方法:回顾性收集2009年1月至2015年12月自贡市第一人民医院收治的年龄≥50岁且符合前列腺穿刺活检指征患者232例,对患者行PSA检测、直肠指诊(digital rectal examination,DRE)和经腹前列腺超声、MRI检查,计算前列腺癌的检出率,分析前列腺癌检出率与年龄、PSA水平的相关关系。结果:本组232例穿刺活检患者中,病理诊断为前列腺癌74例,阳性检出率为31.9%(74/232)。74例患者中,高分化癌16例(21.6%)、中分化癌24例(32.4%)、低分化癌34例(45.9%)。PSA值<4μg/L、4.1~10μg/L、10.1~20μg/L、>20μg/L 4组患者前列腺癌检出率分别为9.1%、13.0%、16.2%、52.3%,随着PSA值的增加,前列腺癌检出率增长明显,呈明显的上升趋势(P<0.001)。随着年龄增高,PSA值也越大,差异有统计学意义(Z=-3.328,P<0.001);年龄<60岁、60~69岁、70~79岁、≥80岁4个年龄组前列腺癌的检出率分别为11.1%、23.6%、40.0%、46.7%,随着年龄的增长,前列腺癌的检出率增长明显(P=0.011)。前列腺穿刺患者前列腺癌检出率与血清PSA值呈正相关(r=0.376,P<0.001),前列腺癌检出率与年龄亦呈正相关(r=0.288,P=0.019)。结论:随着年龄的增加、血清PSA值增高,前列腺穿刺患者前列腺癌的检出率也相应增高。更多还原

【Abstract】 Objective: To investigate the detection rate of prostate cancer and the association between prostate cancer and prostate specific antigen( PSA) and age in patients accepted prostate biopsy. Methods: A retrospective study was conducted in 232 patients over 50 years-old have had prostate biopsy indications in Zigong First People’s Hospital from January 2009 to December 2015. The patients underwent PSA examination,rectal examination digital( DRE) and abdominal ultrasound,and MRI examination. The detection rate of prostate cancer was calculated,and the correlation between tumor detection rate and age,PSA level and pathological grading were analyzed. Results: 74 cases of prostate cancer were diagnosed among the 232 participants,the positive rate were 31. 9%( 74 /232). Among the 74 cases,16 cases( 21. 6%)were well-differentiated cancers,24 cases( 32. 4%) were moderate-differentiated and 34( 45. 9%) were poorly differentiated carcinomas. In the groups of PSA < 4μg / L,4. 1 ~ 10μg / L,10. 1 ~ 20μg / L, > 20μg / L,the prostate cancer detection rate was 9. 1%,13. 0%,16. 2%,52. 3% respectively,with increasing PSA,prostate cancer detection rate increased significantly and showed a statistical significance( P < 0. 001). With the increase of age,the difference was statistically significant( Z =-3. 328,P < 0. 001); < 60 、60 ~ 69 、70 ~ 79 、≥80 years-old the four age groups of prostate cancer detection rate was 11. 1%,23. 6%,40. 0% and 46. 7%respectively,with the increase of the age,prostate cancer detection rate increased significantly( P = 0. 011). There was a significant correlation between the detection rate of prostate cancer and PSA( r = 0. 376,P < 0. 001),and age( r= 0. 288,P = 0. 019). Conclusion: With the increase ofage and the increase of serum PSA,the detection rate of prostate cancer significantly increased.更多还原