【摘要】 目的了解卵胞浆内单精子注射(ICSI)技术对子代学龄前期体格及智力发育的影响。方法使用1:1病例对照研究方法,回顾性随访收集嘉兴市妇幼保健院生殖医学中心行ICSI技术怀孕成功,并在2009年1月至2010年12月间分娩的儿童病例信息,用电话召回,将愿意参加研究的家庭作为ICSI组。在同期本院出生自然怀孕儿童作为对照组。随访家庭一般情况,出生信息,学龄前期体格发育情况,同时进行韦氏学龄前智力测试。结果 ICSI组及对照组各收集到30例。两组均为男16人,女14人,其中ICSI组双胎3对,对照组无。母亲生育年龄,母亲文化程度,父亲生育年龄,父亲文化程度,均未见显著性差异(均P>0.05)。两组分娩方式,出生体重均值,4~6岁身高与体重均与对照组无显著性差异(均P>0.05)。仅出生孕周均值ICSI组低于对照组(37.27±2.392 vs 38.80±1.349),χ2=3.058,P=0.003。韦氏学龄前智力测试结果比较,仅言语商中的图片概括得分ICSI组显著低于对照组(11.00±3.283 vs 13.92±3.283),χ2=2.893,P=0.006。其余各项得分和总智商两组间均无显著性差异(均P>0.05)。结论随访至学龄前期,ICSI子代的体格发育和智力发育情况在正常范围,与自然妊娠儿童发育情况接近。更多还原

【Abstract】 Objective To study the influence of intracytoplasmic sperm injection( ICSI) on physical and intellectual development of children at pre-school stage. Methods A 1: 1 matched case control study was conducted. The information of children conceived by ICSI technology in reproductive medical center of Jiaxing Maternity and Child Health Care Hospital and born during January 2009 to December2010 were collected retrospectively. Families willing to participate in this research were enrolled as ICSI group. The children born during the same period in the hospital were recruited as natural conception group( NC group). Family general conditions,birth information and preschool physical conditions were collected in both groups. Intellectual development was assessed with Chinese-Wechsler preschool and primary scale of intelligence( C-WPPSI). Results Totally 30 children were enrolled in each group,16 males and 14 females. There were3 twins in ICSI group while no twin was in NC group. There was no significant difference in the childbearing age and educational status of parents between two groups( both P > 0. 05). There was no significant difference in mode of delivery,mean birth weight,height and weight of 4-6 years old between two groups( all P > 0. 05). But the mean gestational age of ICSI group was lower than that of NC group( 37. 27 ± 2. 392 vs 38. 80 ± 1. 349)( χ2= 3. 058,P = 0. 003). Comparison of Wechsler preschool intelligence test results showed that only the picture generalization scores in speech quotient of ICSI group were lower than those of NC group( 11. 00 ± 3. 283 vs 13. 92 ± 3. 283)( χ2= 2. 893,P = 0. 006). There was no significant difference between the other scores and the total IQ level between two groups( all P >0. 05). Conclusion Follow-up to preschool age reveals that physical and intellectual development of ICSI offsprings are in the normal range,which is similar to that of natural pregnant children.更多还原