【摘要】 目的探讨联合检测C反应蛋白(CRP)和降钙素原(PCT)在儿童急性淋巴细胞白血病(ALL)白细胞减少合并感染中的临床意义。方法选取2013年12月-2015年12月入院44例ALL白细胞减少合并感染患儿作为感染组,选取同期在门诊复查的ALL未出现并发症的儿童40例作为对照组,比较两组研究对象血清CRP、PCT水平差异。结果感染组患儿血清CRP、PCT水平较对照组显著升高,差异均有统计学意义(t=4.871、3.487,P<0.05)。感染组血清CRP、PCT检测的阳性率明显高于对照组,差异有统计学意义(P<0.05),CRP+PCT联合检测的阳性率为79.55%,显著高于CRP、PCT单独检测(P<0.05)。感染单项指标中,CRP的敏感性较高,PCT特异性较好,综合评价各项性能指标,CRP+PCT联合检测的性能指标更佳。结论在儿童ALL白细胞减少合并感染中,联合检测血清CRP和PCT可提高临床对感染的诊断效率。更多还原

【Abstract】 Objective To explore the clinical significance of combined inspection of C-reactive protein(CRP) and procalcitonin(PCT) in children with acute lymphoblastic leukemia(ALL) and leukopenia and infection. Methods 44 cases of children with acute lymphoblastic leukemia and leukopenia and infection were selected. There were 40 children without complication of acute lymphoblastic leukemia in our hospital selected as control group. Then compare and analyze the value of serum CRP and PCT among these groups. Results The serum CRP and PCT levels of the infection group were significantly higher than those of the control group, the differences were statistically significant(t =4.871,3.487,P <0.05). The positive rate of CRP and PCT in the infection group was significantly higher than that in the control group, the differences were statistically significant(P<0.05). The positive rate of combined detection of PCT and CRP was 79.55%, which was significantly higher than that of CRP and PCT(P <0.05). In the single index of infection, the sensitivity of CRP was higher, and the specificity of PCT was better. Comprehensive evaluation of various performance indicators, combined detection of CRP, PCT performance was the best. Conclusion The combined detection of CRP and PCT method is helpful to improve the diagnose rate of children ALL with leukopenia and infection. It has an important reference for clinical rational drug use, which can avoid using some unnecessary antibiotics to ensure the child patient′s health.更多还原