【摘要】 目的探讨Kin17在宫颈鳞状细胞癌及癌前病变组织中的表达及临床意义。方法应用免疫组织化学方法(Envision法)检测宫颈鳞状细胞癌(SCC)患者(n=88)、宫颈高级别上皮内病变(HSIL)患者(n=8)、宫颈低级别上皮内病变(LSIL)和慢性宫颈炎患者(n=16)中Kin17的表达情况。结果 SCC组、HSIL组和LSIL及慢性宫颈炎组的Kin17阳性表达率分别为72.72%(64/88)、37.50%(3/8)和18.75%(3/16),SCC组阳性表达率明显高于HSIL组、LSIL和慢性宫颈炎组(P<0.05);Kin17表达与SCC患者淋巴结转移相关(P<0.05),即有淋巴结转移组中Kin17表达明显高于无淋巴结转移组;而与患者年龄、FIGO分期、肿瘤分化程度无相关性(P>0.05)。结论 Kin17在宫颈癌的异常表达可能与肿瘤的发生、发展有关,检测Kin17蛋白表达水平可作为监测宫颈癌发生的辅助手段之一。更多还原

【Abstract】 Objective To investigate the expression of Kin17 in cervical squamous cell carcinoma and procacinoma tissues and its significance. Methods The expression of Kin17 was detected by immunohistochemistry(Envision methods) in 88 cases of cervical squamous cell carcinoma(SCC),8 cases of high grade cervical intraepithelial neoplasia(HSIL) and 16 cases of low grade cervical intraepithelial neoplithelail(LSIL) and chronic cervicits. Results The positive expression rate was 72.72% in SCC,37.50% in HSIL and 18.75% in LSIL and chronic cervicits. The positive rate of SCC was significantly higher than those of HSIL and LSIL and chronic cervicits(P<0.05 and P<0.01). In SCC group,there was no significant difference for Kin17 expression in different age,FIGO stage and degree of differentiation(P>0.05),but was associated with lymph node metastasis(P<0.05). Conclusion The disregulated expression of Kin17 may be associated with the development of tumor in cervical squamous cell cancer.It may provide useful biasis for the prognosis of cervical caicinoma. And it may be a supplementary measure for monitoring cervical cancer.更多还原