【摘要】 目的探讨术前及术后贫血对肺大细胞神经内分泌癌(LCNEC)患者预后的影响。方法选取2007年7月—2013年7月于河北医科大学第四医院胸外科治疗的LCNEC患者44例为研究对象,收集患者临床特征资料。以手术日期为观察起点,死亡为临床终点事件计算生存期,随访至2014年8月。结果不同性别、年龄、吸烟史、肿瘤直径、病理类型、TNM分期、手术方式以及是否发生术前及术后贫血、淋巴结转移患者生存时间比较,差异均有统计学意义(P<0.05)。Cox比例风险回归模型分析结果显示,年龄〔HR=6.751,95%CI(3.576,15.438)〕、吸烟史〔HR=3.438,95%CI(1.053,6.538)〕、病理类型〔HR=10.643,95%CI(6.634,21.982)〕、术前贫血〔HR=0.043,95%CI(0.027,0.051)〕、术后贫血〔HR=8.451,95%CI(4.885,9.372)〕、手术方式〔HR=2.334,95%CI(1.658,21.575)〕是LCNEC患者预后的影响因素(P<0.05)。结论术前及术后贫血与LCNEC患者预后有关。更多还原

【Abstract】 Objective To explore the influence of preoperative and postoperative anemia on the prognosis of patients with pulmonary large cell neuroendocrine carcinoma( LCNEC). Methods From July 2007 to July 2013, we enrolled 44 LCNEC patients who received treatment in the Department of Thoracic Surgery of the Fourth Hospital of Hebei Medical University. Data of clinical features of the patients were collected. With the date of surgery as the start point and death as the endpoint,survival time of patients was calculated. The follow- up was conducted until August 2014. Results There were significant differences in survival time among patients with different genders,ages, history of smoking, diameters of tumor,pathological types,TNM stages,surgical methods and between patients with and without preoperative and postoperative anemia,lymph node metastasis( P < 0. 05). Cox proportional hazard regression model analysis showed that age 〔HR = 6. 751,95% CI( 3. 576,15. 438) 〕,history of smoking 〔HR = 3. 438,95% CI( 1. 053,6. 538) 〕,pathological types 〔HR = 10. 643,95% CI( 6. 634,21. 982) 〕, preoperative anemia 〔HR = 0. 043,95% CI( 0. 027,0. 051) 〕, postoperative anemia 〔HR= 8. 451,95% CI( 4. 885,9. 372) 〕 and surgical methods 〔HR = 2. 334,95% CI( 1. 658,21. 575) 〕 were influencing factors for the prognosis of LCNEC patients( P < 0. 05). Conclusion Preoperative and postoperative anemia are related with the prognosis of LCNEC patients.更多还原