【摘要】 目的观察比索洛尔对左室射血分数保留的心力衰竭(HFp EF)患者嗜铬粒蛋白A(Cg A)的影响,探讨Cg A在HFp EF患者中的价值及比索洛尔的治疗效果。方法选取2014年1月~2015年12月于河北医科大学第一医院心血管内科住院并诊断为左室射血分数保留的心力衰竭患者66例,随机分为治疗组和对照组,每组各33例,治疗组给予比索洛尔加标准化治疗,对照组仅给予标准化治疗。2周后检测两组患者Cg A水平、监测超声心动图变化。结果两组患者治疗前Cg A、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末内经(LVESD)、E峰、A峰、E/A、左室等容舒张时间(IVRT)指标差异无统计学意义(P>0.05)。治疗后,以上观察指标治疗组的改善情况均优于对照组(P<0.05);治疗组总有效率优于对照组(87.87%vs.63.63%,P<0.05)。结论比索洛尔治疗HFp EF患者效果显著,Cg A为HFp EF患者的病情判断及预后提供了一定的临床价值。更多还原

【Abstract】 Objective To investigate the effects of bisoprolol on chromaffin granule protein A(Cg A) in heart failure patients with preserved left ventricular ejection fraction(HFp EF), and to explore the role of Cg A in HFp EF patients and the treatment effect of bisoprolol. Methods 66 chronic heart failure patients were randomly divided into treatment group and control group(33 patients in each group). Treatment group was given bisoprolol and standardized treatment, the control group was only given standardized treatment. Cg A level and change of echocardiography were measured two weeks after treatment in two groups. Results There is no difference as to Cg A level, left ventricular ejection fraction(LVEF), left ventricular end-diastolic diameter(LVEDD), left ventricular end-systolic diameter(LVESD), E peak, A peak, E/A and left ventricular isovolumic relaxation time(IVRT) between two groups before treatment(P>0.05). After treatment, all the indexes above in treatment group were improved better than control group(P<0.05). The total effective rate in treatment group was higher than control group(87.87% vs. 63.63%, P<0.05). Conclusion The effect of bisoprolol on HFp EF patients is remarkable. Cg A is useful for condition judgment and prognosis of HFp EF patients.更多还原