【摘要】 目的分析慢性心力衰竭(CHF)患者血清同型半胱氨酸(Hcy)和脑钠肽(BNP)水平变化和与危险分层的相关性。方法连续纳入2012年2月~2014年12月期间在安徽省合肥市第二人民医院心内科住院的慢性心力衰竭患者(CHF),共93例。对照组入选同期住院的无心力衰竭的患者61例;CHF组按照NYHA心功能分级法分Ⅱ级(n=48)、Ⅲ级(n=28)、Ⅳ级(n=22)3个亚组,各组分别测量Hcy、BNP等相关指标。采用超声多普勒测量左心室质量(LVM),结合体表面积计算出左心质量指数(LVMI)。分别比较CHF组和对照组及CHF各心衰亚组间Hcy水平的差异,及Hcy和BNP与LVMI的相关性。结果 CHF组血清Hcy、BNP水平明显高于对照组,差异有统计学意义(P<0.05);并且随着心功能分级的增加,血清Hcy、BNP水平亦明显增高(P<0.05);Hcy和BNP、LVMI呈正相关(r=0.382,P<0.05),差异有统计学意义。结论血清Hcy水平变化可一定程度上反映心力衰竭的病情变化。更多还原

【Abstract】 Objective To analyze the changes of levels of homocysteine(Hcy) and brain natriuretic peptide(BNP), and correlation among them and risk stratification of chronic heart failure(CHF). Methods CHF patients(n=93) were chosen continuously from Feb. 2012 to Dec. 2014 as CHF group, and other patients without CHF(n=61) were chosen at the same time as control group. CHF group was divided again into II-grade subgroup(n=48), III-grade subgroup(n=28) and IV-grade subgroup(n=22) according to NYHA grading method. The levels of Hcy and BNP were detected in all groups. The changes of left ventricular mass(LVM) were detected by using color Doppler echocardiogram, and left ventricular mass index(LVMI) was calculated. The difference in Hcy level was analyzed between CHF group and control group and among all subgroups. The correlation between Hcy and BNP or LVMI was studied. Results The levels of Hcy and BNP was significantly higher in CHF group than those in control group(P<0.05). As the increase of NYHA grade, the levels of Hcy and BNP increased significantly(P<0.05). Hcy was correlated positively to BNP or LVMI(r=0.382, P<0.05). Conclusion The changes of serum Hcy level can reflect the changes of CHF to some extent.更多还原