【摘要】 目的观察经尿道膀胱肿瘤电切加黏膜下注射吡柔比星及α-干扰素在减少浅表性膀胱癌复发中的作用。方法浅表性膀胱癌患者按入院先后次序随机分成两组,最后79例纳入研究,包括对照组42例,经尿道膀胱肿瘤电切后吡柔比星即刻膀胱灌注加维持膀胱灌注化疗;观察组37例,经尿道膀胱肿瘤电切后随即膀胱镜下行膀胱黏膜下吡柔比星、α-干扰素注射。对比两组患者术后肿瘤复发率、复发时间、拔除导尿管后尿频持续时间、发热及白细胞异常降低发生率等情况。结果所有患者全部顺利完成手术。随诊3年,对照组复发16例,复发率38.1%,平均复发时间7.4个月,发热2例。观察组复发7例,复发率18.9%,平均复发时间11.2个月,发热25例。两组患者术后肿瘤复发率、复发时间、发热发生率等方面差异有统计学意义;术后拔除导尿管后尿频持续时间两组差异无统计学意义;两组均无白细胞异常降低发生。结论经尿道膀胱肿瘤电切术加黏膜下注射吡柔比星及干扰素安全有效,可减少浅表性膀胱癌的术后复发。更多还原

【Abstract】 Objective To investigate the effect of transurethral resection of bladder tumor(TURBT)combined with submucosal injection of Pirarubicin and Interferon to control the recurrence of superficial bladner cancer. Methods 79 suprficial bladder cancer patients were randomly divided into two groups.In control group,42 patients underwent routine bladder irrigation after TURBT.In observe group,37 patients received submucosal injection of Pirarubicin Hydrochloride andα-Interferon after TURBT immediately.Recurrence rate,mean recurrence time,frequent micturition duration after removal catheter,rate of fever and leukocytopenia were compared between these two groups.Results All the operations were succeed.Follow-up of 3years,16 patients recurred in control group,the recurrence rate is 38.1%,mean recurrence time is 7.4months.In observe group,7patients recurred,the recurrence rate is 18.9%,mean recurrence time is 11.2 months.Recurrence rate,mean recurrence time,frequent micturition duration after removal catheter,rate of fever were difference significantly in statistic.Leukocytopenia didn’t occure in the two groups. ConclusionsInjection of Pirarubicin and Interferon sub-mucosal after TURBT is a safe and effective method in prevention superficial bladder cancer recurrence.更多还原