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新型拟肽cyclo[-RGD-ψ(triazole)-GD-]波谱学数据与结构确证
An NMR Spectroscopy Study on Peptidomimetics Cyclo[-RGD-ψ(triazole)-GD-]
【摘要】 多肽RGD是一类含有精氨酸-甘氨酸-天冬氨酸(Arg-Gly-Asp)序列的短肽,该文对新型环状拟肽cyclo[-RGD-ψ(triazole)-GD-]的紫外吸收光谱(UV)、红外吸收光谱(FT-IR)进行了分析,并利用核磁共振(NMR)波谱(包括1H NMR、1H-1H COSY、13C NMR、DEPT、1H-13C HSQC和1H-13C HMBC)对其1H和13C NMR信号进行了全归属.
【Abstract】 The spectral data of peptidomimetics cyclo[-RGD-ψ(triazole)-GD-] were reported, including UV, FT-IR and NMR(i.e., 1H NMR, 1H-1H COSY, 13 C NMR, DEPT, 1H-13 C HSQC and 1H-13 C HMBC). The NMR signals were assigned. The infrared spectrum was analyzed to derive the types of vibrations of the functional groups in the compound. The molecular structure of peptidomimetics cyclo[-RGD-ψ(triazole)-GD-] was determined.
【关键词】 拟肽;
核磁共振(NMR);
归属;
化学位移;
结构确证;
【Key words】 peptidomimetics; NMR; assignment; chemical shift; structural elucidation;
【Key words】 peptidomimetics; NMR; assignment; chemical shift; structural elucidation;
【基金】 浙江省科技厅公益性技术应用研究计划资助项目(2015C37007);浙江大学实验技术资助项目(SYB201402)
- 【文献出处】 波谱学杂志 ,Chinese Journal of Magnetic Resonance , 编辑部邮箱 ,2016年02期
- 【分类号】O629.72
- 【被引频次】1
- 【下载频次】80