【摘要】 目的观察脾氨肽口服冻干粉与重组人干扰素α-2b乳膏联合治疗青少年扁平疣的临床疗效和对免疫功能的影响。方法 187例患者随机分为2组,治疗组96例口服脾氨肽冻干粉与外擦重组人干扰素α-2b乳膏,疗程2月;对照组91例仅外擦重组人干扰素α-2b乳膏。治疗前后应用流式细胞仪检测外周血T淋巴亚群,酶联免疫吸附实验检测血清中白介素-2（IL-2）、白介素-4（IL-4）和γ干扰素（INF-γ）的水平,并与25例健康正常人组比较。结果治疗组总有效率88.54%,对照组总有效74.72%,差异有统计学意义（P<0.05）。两组治疗前外周血CD₄⁺、CD₄⁺/CD₈⁺比值及IL-2、INF-γ水平均明显低于健康组（P<0.01）;治疗组治疗后上述指标均显著升高（P<0.01）,与健康组对照差异无显著性（P>0.05）。对照组治疗后上述指标有所升高（P<0.05）,但仍低于健康组（P<0.05）。两组治疗前外周血CD₈⁺、IL-4水平均高于健康组（P<0.05）,两组治疗后均下降（P<0.05）,但治疗组下降幅度大于对照组,与健康组对照差异无统计学差异（P>0.05）。结论脾氨肽口服冻干粉联合重组人干扰素α-2b乳膏外擦治疗青少年扁平疣疗效显著,可以提高患者免疫功能,且无明显不良反应,值得临床应用。更多还原

【Abstract】 Objective To investigate the clinical efficacy of spleen aminopeptide oral lyophilized powder combined with recombinant human interferon α2 b ointment to treat verruca plana in adolescents,and its effect on levels of Tlymphocyte subsets,interleukin-2（ IL- 2）,interleukin- 4（ IL- 4） and interferon-gamma（ INF-γ） in peripheral blood. Methods 187 patients were randomly divided into 2 groups. The treatment group of 96 cases was treated by internal use of spleen aminopeptide oral lyophilized powder combined with external application of recombinant human interferon α2b ointment. The course of treatment was 2 months. The control group of 91 cases was only treated by external application of recombinant human interferon α2b ointment. Before and after the treatment,T-lymphocyte subsets in peripheral blood of all the patients were determined by flow cytometry,and serum levels of IL- 2,IL- 4 and INF-γ were detected by ELISA. The same detections were also done to the 25 healthy volunteers as healthy control group. Results The total effective rate of the treatment group was 88.54%,and the control group was 74.72%. There was a significant statistically difference between the two groups（ P<0.05）. Decrease of CD₄⁺cells,CD₄⁺/ CD₈⁺ratio,and IL-2,INF- γ in serum were found in varruca plana group as compared with healthy control group before the treatment（ P<0.01）. After the treatment,the above indexes of treatment group increased significantly（ P < 0. 01）,and there were no significant difference compared with healthy control group（ P >0.05）,while the above indexes of control group were increased（ P<0.05）,but those were still lower than in healthy control group. Increase of CD₈⁺cells,IL-4 in serum were found in varruca plana group as compared with healthy control group before the treatment（ P<0.05）. After the treatment,the above indexes of two groups decreased significantly（ P<0.05）,but the above indexes of treatment group declined more than control group,which there were no significant difference compared with healthy control group（ P>0.05）. Conclusion Spleen aminopeptide oral lyophilized powder and external application of recombinant human interferon α2b ointment in the treatment of verruca plana are confirmed effective in adolescent patients,with the immune function of patients improved and no obvious adverse reaction. It is worthy of clinical application of verruca plana.更多还原