Doramectin is a novel macrolide antibiotics derived from avermectin and widely used as an antiparasitic drug in animal husbandry. Doramectin can be produced by genetically modified Streptomyces avermitilis with altered avermectin synthesis pathways. Disruption of branched- chain alpha- keto acid dehydrogenase gene cluster(bkd FGH), which encodes the components of the branched-chain alpha-keto acid dehydrogenase(BCDH) complex multi- enzyme system, can direct S. avermitilis to produce effective doramectin(CHC...
【基金】
国家转基因生物新品种培育科技重大专项(No.2009ZX08009-151B)
【更新日期】
2016-03-08
【分类号】
Q939.9
【正文快照】
阿维菌素(avermectin)是由阿维链霉菌(Strepto-myces avermitilis)产生的一组结构类似的十六元大环内酯类化合物,具有广谱而高效的驱虫和杀虫活性,其生物合成基因和合成步骤已基本阐明(Ikedaet al.,2014;Thuan et al.,2014;Zhuo et al.,2014)。多拉菌素(doramectin)是由美国辉?
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