【摘要】 目的:探讨基于社区人群的中老年男性血清生殖激素及同型半胱氨酸(Hcy)水平与代谢综合征(MS)及其组分之间的相互关系。方法:以农村社区人口为基础,采用整群及年龄分层抽样相结合的方法,调查中老年男性948例。采用统一的结构式问卷进行调查,测量其基本身体参数,检测其血清生殖激素、Hcy浓度和代谢指标。本研究共获得有效问卷与血清样本868份。将研究对象按照是否患有MS,划分成MS组和非MS(NMS)组,并且按照1∶1设立对照组测定其血清Hcy浓度进行研究。结果:132例诊断为MS。经非参数检验,两组间年龄无统计学差异(P>0.05),腰围(WC)、腰臀比(WHR)、体质指数(BMI)、收缩压(SBP)、舒张压(DBP)均有显著性差异(P均<0.05)。两组间实验室参数进行比较,其中总睾酮(t T)、性激素结合球蛋白(SHBG)、黄体生成素(LH)和游离睾酮指数(FTI)均有显著差异(P均<0.05),但Hcy浓度无统计学差异(P>0.05)。Hcy与MS危险因素的关联研究中,Hcy与BMI、SBP、DBP、FBG、TG、HDL-C均无相关性(P均>0.05)。MS相关因素的Logistic回归分析显示Hcy对MS无显著影响。结论:血清Hcy与MS未见显著相关性,与MS各个组分也未见显著相关性。男性血清生殖激素与MS及其各个组分存在不同程度的显著相关性。更多还原

【Abstract】 Objective: To investigate the relationship among serum reproductive hormone levels,serum homocysteine( Hcy)levels,metabolic syndrome( MS),and the components of MS in middle-aged and elderly males. Methods: Using the cluster and stratified sampling methods and a unified structured questionnaire,we conducted a survey among 948 men aged 40- 80 years in the rural community,measured their basic physical parameters,and obtained their reproductive hormone levels,serum Hcy concentrations,and metabolism-related indicators. We collected 868 valid questionnaires along with their serum samples,divided the subjects into an MS and a non-MS control group in a 1∶ 1 ratio,and measured their serum Hcy concentrations. Results: Among the subjects included,132 were diagnosed with MS. Nonparametric tests showed statistically significant differences between the MS and non-MS groups in the waist circumference( WC),waist-hip ratio( WHR),body mass index( BMI),systolic blood pressure( SBP),and diastolic blood pressure( DBP)( P < 0. 05),but not in age( P > 0. 05). Significant differences were also observed between the two groups in the levels of serum t T,SHBG,LH,and FTI( P < 0. 05),but not in the concentrations of serum Hcy( P > 0. 05). The concentration of serum Hcy exhibited no correlation with BMI,SBP,DBP,FBG,TG,and HDL-C( P > 0. 05) and had no influence on MS. Conclusion: The concentration of serum Hcy is not significantly correlated with MS,nor with its components. The levels of male serum reproductive hormones are associated both with MS and with its components.更多还原