【摘要】 抗中性粒细胞胞浆抗体(antineutrophil cytoplasmic antibody,ANCA)是ANCA相关血管炎的标志性抗体。近年来的研究已证实,ANCA不仅是一种生物学标志物,其本身还具有重要的致病作用,如ANCA可以激活中性粒细胞,激活补体,并诱导中性粒细胞对内皮细胞的损伤,而ANCA的致病性又受其本身免疫学特性的影响,故ANCA可能作为未来ANCA相关血管炎治疗的靶点。本文主要对近年来关于ANCA致病机制的研究进展进行综述。更多还原

【Abstract】 Antineutrophil cytoplasmic antibody(ANCA) is a biomarker of ANCA associated vasculitis. Recentstudies have demonstrated that ANCA is not only a biological marker, but also plays an important pathogenic role.ANCA can activate neutrophils, activate complement, and induce the damage of neutrophils to endothelial cells. Onthe other hand, the pathogenic role of ANCA is also influenced by the immunological characteristics of the ANCAitself. Thus, ANCA may serve as a potential target for the treatment of ANCA associated vasculitis in the future. Theprogress of the research about the pathogenesis of ANCA in recent years is to be reviewed in this paper.更多还原