【摘要】 目的探讨甲基多巴联合拉贝洛尔治疗妊娠高血压的疗效及其对患者血清同型半胧氨酸(homocysteine,Hcy)及高敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)浓度的影响。方法将82例妊娠高血压患者按照治疗方法分为对照组(n=40)与观察组(n=42),对照组采用硫酸镁治疗,观察组在此基础上采用甲基多巴联合拉贝洛尔治疗。比较两组患者治疗前后血压、24 h尿蛋白定量、血浆黏度、病情评分、血清Hcy及hs-CRP浓度。结果(1)两组治疗后血压、24h尿蛋白定量、血浆黏度、血清Hcy及hs-CRP浓度均显著低于治疗前,差异有统计学意义(P<0.05);且观察组治疗后上述指标水平均显著低于对照组治疗后,差异有统计学意义(P<0.05)。结论甲基多巴联合拉贝洛尔治疗妊娠高血压的疗效显著,可通过降低患者血清Hcy及hs-CRP浓度而发挥作用,应在临床上进行推广。更多还原

【Abstract】 Objectives To investigate the therapeutic effect of methyldopa combined with labetalol on patients with pregnancy-induced hypertension and its effect on serum concentrations of homocysteine(Hcy) and hypersensitive Creactive protein(hs-CRP).Methods Totally 82 patients with pregnancy-induced hypertension were randomly divided into two groups according to treatment theraphy:control group(n=40) and observation group(n=42).Patients in control group were treated with magnesium sulfate,and patients in observation group were treated with methyldopa joint labetalol on this basis of magnesium sulfate therapy.Blood pressure,24 h urinary protein excretion,plasma viscosity,disease rates,serum concentrations of Hcy and hs-CRP were compared before and after treatment between the two groups.Results After treatment,blood pressure,24 h urinary protein excretion,plasma viscosity,serum concentrations of Hcy and hs-CRP of the two groups were significantly lower than those before treatment(P<0.05);and the indexes in observation group were significantly lower than those in control group(P<0.05).Conclusions Therapy of methyldopa joint labetalol is significantly effective to pregnancy-induced hypertension by reducing serum concentrations of Hcy and hs-CRP.It should be carried out in clinical practice.更多还原