【摘要】 目的探讨血清γ谷氨酰转移酶(gamma-glutamyl transferase,γ-GGT)对急性心力衰竭(acute heart failure,AHF)患者病死率的预测价值。方法将188例AHF患者分为死亡组和存活组,所有患者行生物化学以及血清γ-GGT浓度检测,分析两组患者的血清γ-GGT浓度及临床生化指标的差异。结果两组血清γ-GGT浓度、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、血尿素氮(blood urea nitrogen,BUN)、血肌酐(creatinine,Cr)、肌酸激酶(creatine kinase,CK)、肌酸激酶同工酶(creatine kinase isoenzyme MB,CK-MB)、总胆汁酸(total bile acid,TBA)、心房脑钠肽(brain natriuretic peptide,BNP)浓度,射血分数(ejection fraction,EF)及合并原发性高血压(高血压)、心房纤颤患者比例比较,差异具有统计学意义(P<0.05)。应用Logistic回归分析显示,血清γ-GGT浓度为AHF患者的危险因素(P<0.05)。血清γ-GGT浓度对于AHF病死率的诊断的敏感度78.9%,特异度66.7%,受试者工作曲线下面积为0.759。结论血清γ-GGT浓度可能可以作为预测AHF的病死率的血清指标,具有一定的临床应用价值。更多还原

【Abstract】 Objectives To explore the predictive value of serum gamma-glutamyl transferase( "y-GGT) on mortality in patients with acute heart failure(AHF).Methods A total of 188 patients with AHF were divided into death group and survival group.Biochemical indexes and serum concentration of " y-GGT were tested in all the patients to analyze the differences between the two groups.Results There were significant differences in serum concentrations of "y-GGT,high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),blood urea nitrogen(BUN),creatinine(Cr),creatine kinase isoenzyme MB(CK-MB),total bile acid(TBA),brain natriuretic peptide(BNP),ejection fraction(EF) and percentages of patients with atrial firillation,hypertension between the two groups(P<0.05).Logistic regression analysis showed that serum concentration of " y-GGT was an independent risk factor in patients with AHF(P<0.05).The sensitivity and specificity were 78.9%and 66.4%with a cutoff value of 35.5 U/L.The area under the receiver operating characteristic curve was 0.759.Conclusions Serum concentration of γ-GGT may be a predictor of mortality in patients with AHF.It has clinical diagnostic value to a certain extent.更多还原