Purpose To study the relationship between high-risk human papilloma viruses( HR-HPV) genotype and the progression of cervical lesions. Methods HPV genotype and E6 / E7 mRNA of 135 cervical biopsy tissues embedded by paraffin which contained 45non-squamous intraepithelial lesions( NSIL),42 low-grade squamous intraepithelial lesions( LSIL),40 high-grade squamous intraepithelial lesions( HSIL),and 8 squamous cervical cancers( SCC) were detected by the methods of PCR-reverse hybridization and branched DNA( b DN...
【基金】
河南省科技攻关计划(142102310395)
【更新日期】
2016-10-08
【分类号】
R737.33
【正文快照】
子宫颈癌(squamous cervical cancer,SCC)属于常见的恶性肿瘤,居全球女性发病率的第二位,每年
约50万的新发病例[1]。人类乳头状瘤病毒(human papilloma viruses,HPV)被认为是引起女性SCC癌变的首要因素,其中高危型人类乳头状瘤病毒(high-risk human papilloma viruses,HR-HPV