【摘要】 目的探讨肿瘤患者血清NT-pro BNP、TNI和CK-MB水平及其临床意义。方法收集深圳市南山区人民医院2010年10月至2015年10月住院治疗的249例肿瘤患者（肿瘤组）和250例正常体检的患者（对照组）,排除有冠心病、心力衰竭等疾病,检测和比较其血清NT-pro BNP、TNI和CK-MB水平,并分析其与肿瘤患者死亡风险的相关性。结果肿瘤组初发阶段血清TNI为（0.085±0.0135）ng·m L^-1,NT-pro BNP水平为（78.45±19.61）pg·mL^-1,均较对照相显著升高,差异具有统计学意义（P<0.001）;两组血清CK-MB水平比较差异不具有统计学意义（P=0.654）。随着肿瘤分期的进展,患者血清NT-pro BNP、TNI和CK-MB水平逐渐升高,不同分期之间比较,差异均具有统计学意义（P<0.05）。血清NT-pro BNP、TNI和CK-MB水平与肿瘤患者的死亡风险相关,其值越高,患者的死亡风险越大。结论肿瘤患者的血清NT-pro BNP和TNI水平可能作为判断肿瘤患者病情进展和进行预后评估的参考指标。更多还原

【Abstract】 Objectives To investigate the serum levels and clinical significances of NT-pro BNP,TNI and CK-MB in cancer patients. Methods 249 cases of cancer patients（the tumor group）hospitalized in Shenzhen Nanshan District People’s Hospital from October 2010 to October 2015 and 250 physically normal patients（the control group）were included in this project. The coronary disease and heart failure were excluded. The NT-pro BNP and TNI as well as CK-MB levels were detected and compared,and their correlation with the risk of death was analyzed. Results During the primary stage of cancer,the serum levels of TNI and NT-pro BNP were respectively（0.085±0.0135）ng·mL^-1 and（78.45±19.61）pg·mL^-1 Both were significantly higher than those of the control group（P<0.001）. However,there was no statistically significant difference in serum CK-MB levels between the two groups（P=0.654）. With the progression of tumor stage,the serum levels of NT-pro BNP,TNI and CK-MB increased significantly,and significant difference between different stages were observed（P<0.05）. The serum levels of NT-pro BNP,TNI and CK-MB were positively correlated with the death risk. The higher the serum levels of NT-pro BNP,TNI and CK-MB were,the higher the death risk was. Conclusions The serum NT-pro BNP and TNI levels could be used as references in evaluating the progress and prognosis of cancer patients.更多还原