【摘要】 以L-色氨酸为原料,经Pictet-Spengler、酯化、氧化等反应合成1 6个β-咔啉-3-羧酸酯二聚体化合物,其中14个为新化合物.化合物结构经¹H NMR、¹³C NMR、ESI-MS确认.利用MTT法测试其体外抗肿瘤活性,结果表明β-咔啉-3-羧酸二聚化能明显提高其抑制肿瘤细胞的活性,且以戊烷链连接的二聚体活性最好.更多还原

【Abstract】 Sixteen β-carboline-3-carboxylate ester dimmers（including fourteen new compounds） were synthesized from L-tryptophan via Pictet-Spengler esterification and oxidation reaction and their structure were confirmed by ¹H NMR,¹³C NMR,ESI-MS.Their antitumor activity in vitro was determined by MTT assay.The results showed that the dimerization of β-carboline-3-carboxylic acid played an important role in increasing the antitumor activities.In particular,the dimers with the pentane chain linked were the best.更多还原